Role of Dopamine D4 Receptors in Motor Hyperactivity Induced by Neonatal 6-Hydroxydopamine Lesions in Rats

被引：0
作者：
Kehong Zhang
Frank I Tarazi
Ross J Baldessarini
机构：
[1] Mailman Research Center,McLean Division of Massachusetts General Hospital
[2] Harvard Medical School,Consolidated Department of Psychiatry and Neuroscience Program
来源：
Neuropsychopharmacology | 2001年 / 25卷
关键词：
Attention deficit-hyperactivity disorder; Autoradiography; Dopamine; D; 6-hydroxydopamine; Motor activity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The role of dopamine D4 receptors in behavioral hyperactivity was investigated by assessing D4 receptor expression in brain regions and behavioral effects of D4 receptor-selective ligands in juvenile rats with neonatal 6-hydroxydopamine lesions, a laboratory model for attention deficit-hyperactivity disorder (ADHD). Autoradiographic analysis indicated that motor hyperactivity in lesioned rats was closely correlated with increases in D4 but not D2 receptor levels in caudate-putamen. D4-selective antagonist CP-293,019 dose-dependently reversed lesion-induced hyperactivity, and D4-agonist CP-226,269 increased it. These results indicate a physiological role of dopamine D4 receptors in motor behavior, and may suggest much-needed innovative treatments for ADHD.
引用
收藏
页码：624 / 632
页数：8
相关论文
共 255 条
[1]  
Ariano MA(1997)Cellular distribution of the rat D Brain Res 752 26-34
[2]  
Wang J(1995) dopamine receptor protein in the CNS using anti-receptor antisera J Biochem 65 1157-1165
[3]  
Noblett KL(1994)Modulation of intracellular cyclic AMP levels by different human dopamine D Mol Pharmacol 46 364-373
[4]  
Larson ER(1997) receptor variants Am J Med Genet Neuropsychiat Genet 74 623-624
[5]  
Sibley DR(1997)Dopamine D Psychol Bull 121 65-94
[6]  
Asghari V(1992) receptor repeat: Analysis of different native and mutant forms of the human and rat genes J Abnorm Child Psychol 20 163-188
[7]  
Sanyal S(1996)DRD4 gene and susceptibility to attention deficit hyperactivity disorder Nature Genetics 12 81-84
[8]  
Buchwaldt S(1985)Behavioral inhibition, sustained attention, and executive functions: Constructing a unifying theory of ADHD Behav Neurosci 99 771-775
[9]  
Paterson A(1990)Frontal lobe functions in attention deficit disorder with and without hyperactivity: a review and research report Behav Brain Res 37 157-168
[10]  
Jovanovic V(1999)Population and familial association between D Am J Med Genet 88 358-368
12345678910