Urolithin A inhibits enterovirus 71 replication and promotes autophagy and apoptosis of infected cells in vitro

被引：0
作者：
Shengyu Wang
Junhua Qiao
Yaping Chen
Langfei Tian
Xin Sun
机构：
[1] Zunyi Medical University,Key Laboratory of Infectious Disease & Biosafety, Provincial Department of Education, Institute of Life Sciences, College of Preclinical Medicine
[2] Zunyi Medical University,Department of Microbiology, College of Preclinical Medicine
来源：
Archives of Virology | 2022年 / 167卷
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摘要：
Hand, foot, and mouth disease (HFMD) is a serious threat to the health of infants, and it can be caused by enterovirus 71 (EV71). The clinical symptoms are mostly self-limiting, but some infections develop into aseptic meningitis with poor prognosis and even death. In this study, urolithin A (UroA), an intestinal metabolite of ellagic acid, significantly inhibited the replication of EV71 in cells. Further evaluation showed that UroA was better than ribavirin in terms of its 50% cytopathic concentration (CC50), 50% inhibitory concentration (IC50), and selectivity index. Moreover, UroA inhibited the proliferation of EV71 by promoting autophagy and apoptosis of infected cells. Therefore, UroA is a candidate drug for the treatment of EV71 infection.
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页码：1989 / 1997
页数：8
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  • [1] Alfei S(2020)Oxidative stress, antioxidant capabilities, and bioavailability. Ellagic acid or urolithins? Antioxidants 2 9-720
  • [2] Marengo B(2020)Antiinflammatory and anti-cancer activities of pomegranate and its constituent, ellagic acid: Evidence from cellular, animal, and clinical studies Phytother Res 34 685-126
  • [3] Zuccari G(2001)Host defense, viruses and apoptosis Cell Death Differ 8 113-348
  • [4] Baradaran Rahimi V(2013)The role of 'eat-me' signals and autophagy cargo receptors in innate immunity Curr Opin Microbiol 16 339-354
  • [5] Ghadiri M(2018)Experimental evidence of the antitumor, antimetastatic and antiangiogenic activity of ellagic acid Nutrients 10 2-165
  • [6] Ramezani M(2018)Autophagy during viral infection—a double-edged sword Nat Rev Microbiol 16 341-5632
  • [7] Askari VR(2020)Ellagic acid and urolithins a and b differentially regulate fat accumulation and inflammation in 3T3-L1 adipocytes while not affecting adipogenesis and insulin sensitivity Int J Mol Sci 21 2-1252
  • [8] Barber GN(2013)Biological significance of urolithins, the gut microbial ellagic Acid-derived metabolites: the evidence so far Evid Based Complement Alternat Med 2 2-820
  • [9] Boyle KB(1999)Apoptosis: an innate immune response to virus infection Trends Microbiol 7 160-413
  • [10] Randow F(2008)Viral control of mitochondrial apoptosis PLoS Pathog 4 e1000018-4565
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