Microhomology-mediated end joining: new players join the team

被引：0
作者：
Hailong Wang
Xingzhi Xu
机构：
[1] Capital Normal University,Beijing Key Laboratory of DNA Damage Response and College of Life Sciences
[2] Shenzhen University School of Medicine,undefined
来源：
Cell & Bioscience | / 7卷
关键词：
DNA double-strand breaks (DSBs); Microhomology-mediated end joining (MMEJ); End resection; RPA; Polθ;
D O I：
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摘要：
DNA double-strand breaks (DSBs) are the most deleterious type of DNA damage in cells arising from endogenous and exogenous attacks on the genomic DNA. Timely and properly repair of DSBs is important for genomic integrity and survival. MMEJ is an error-prone repair mechanism for DSBs, which relies on exposed microhomologous sequence flanking broken junction to fix DSBs in a Ku- and ligase IV-independent manner. Recently, significant progress has been made in MMEJ mechanism study. In this review, we will summarize its biochemical activities of several newly identified MMEJ factors and their biological significance.
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