Abstract reward and punishment representations in the human orbitofrontal cortex

被引：0
作者：
J. O'Doherty
M. L. Kringelbach
E. T. Rolls
J. Hornak
C. Andrews
机构：
[1] University of Oxford,Department of Experimental Psychology
[2] Oxford Centre for Functional Magnetic Resonance Imaging (FMRIB),undefined
[3] John Radcliffe Hospital,undefined
来源：
Nature Neuroscience | 2001年 / 4卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The orbitofrontal cortex (OFC) is implicated in emotion and emotion-related learning. Using event-related functional magnetic resonance imaging (fMRI), we measured brain activation in human subjects doing an emotion-related visual reversal-learning task in which choice of the correct stimulus led to a probabilistically determined 'monetary' reward and choice of the incorrect stimulus led to a monetary loss. Distinct areas of the OFC were activated by monetary rewards and punishments. Moreover, in these areas, we found a correlation between the magnitude of the brain activation and the magnitude of the rewards and punishments received. These findings indicate that one emotional involvement of the human orbitofrontal cortex is its representation of the magnitudes of abstract rewards and punishments, such as receiving or losing money.
引用
收藏
页码：95 / 102
页数：7
相关论文
共 50 条
[41]   Value and choice as separable and stable representations in orbitofrontal cortex [J].
Daniel L. Kimmel ;
Gamaleldin F. Elsayed ;
John P. Cunningham ;
William T. Newsome .
Nature Communications, 11
[42]   Representations of appetitive and aversive information in the primate orbitofrontal cortex [J].
Morrison, Sara E. ;
Salzman, C. Daniel .
CRITICAL CONTRIBUTIONS OF THE ORBITOFRONTAL CORTEX TO BEHAVIOR, 2011, 1239 :59-70
[43]   Human orbitofrontal cortex mediates extinction learning while accessing conditioned representations of value [J].
Gottfried, JA ;
Dolan, RJ .
NATURE NEUROSCIENCE, 2004, 7 (10) :1145-1153
[44]   Crossmodal associative memory representations in rodent orbitofrontal cortex [J].
Lipton, PA ;
Alvarez, P ;
Eichenbaum, H .
NEURON, 1999, 22 (02) :349-359
[45]   Human orbitofrontal cortex mediates extinction learning while accessing conditioned representations of value [J].
Jay A Gottfried ;
Raymond J Dolan .
Nature Neuroscience, 2004, 7 :1144-1152
[46]   Value and choice as separable and stable representations in orbitofrontal cortex [J].
Kimmel, Daniel L. ;
Elsayed, Gamaleldin F. ;
Cunningham, John P. ;
Newsome, William T. .
NATURE COMMUNICATIONS, 2020, 11 (01)
[47]   Synaptic and spiking dynamics underlying reward reversal in the orbitofrontal cortex [J].
Deco, G ;
Rolls, ET .
CEREBRAL CORTEX, 2005, 15 (01) :15-30
[48]   Differential coding of uncertain reward in rat insular and orbitofrontal cortex [J].
Suhyun Jo ;
Min Whan Jung .
Scientific Reports, 6
[49]   Prospective Coding of Dorsal Raphe Reward Signals by the Orbitofrontal Cortex [J].
Zhou, Jingfeng ;
Jia, Chunying ;
Feng, Qiru ;
Bao, Junhong ;
Luo, Minmin .
JOURNAL OF NEUROSCIENCE, 2015, 35 (06) :2717-2730
[50]   Re-evaluating the role of the orbitofrontal cortex in reward and reinforcement [J].
Noonan, M. P. ;
Kolling, N. ;
Walton, M. E. ;
Rushworth, M. F. S. .
EUROPEAN JOURNAL OF NEUROSCIENCE, 2012, 35 (07) :997-1010
12345