Aggregator compounds confound amyloid fibrillization assay

被引：0
|
作者：
Gilbert M Rishton
机构：
[1] Gilbert M. Rishton is director of the Channel Islands Alzheimer's Institute,
[2] CSUCI,undefined
[3] Aliso Hall,undefined
[4] One University Drive,undefined
[5] Camarillo,undefined
[6] California 93012,undefined
[7] USA. gilbert.rishton@csuci.edu,undefined
来源：
Nature Chemical Biology | 2008年 / 4卷
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摘要：
The highly sensitive and artificial biochemical assays that enable high-throughput screening are vulnerable to artifact-generating compounds that occur in drug screening collections. An investigation of known aggregator compounds and amyloid fibrillization inhibitors suggests that such inhibitors operate via a nonspecific mechanism in a well-used assay of amyloid fibrillization.
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页码：159 / 160
页数：1
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