Metabolism of clozapine by rat brain: the role of flavin-containing monooxygenase (FMO) and cytochrome P450 enzymes

被引：0
作者：
J. Fang
机构：
[1] University of Alberta,Neurochemical Research Unit, Department of Psychiatry
[2] University of Saskatchewan,College of Pharmacy and Nutrition
来源：
European Journal of Drug Metabolism and Pharmacokinetics | 2000年 / 25卷
关键词：
Clozapine; biotransformation; brain; rat; flavin-containing monooxygenase (FMO); cytochrome P450;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The atypical antipsychotic clozapine has been reported to be metabolised mainly to its N-oxide and N-demethylated products. Brain, the target organ of clozapine, is known to contain numerous drug-metabolising enzymes which could alter the local concentrations of the drug. The metabolism of clozapine was, therefore, studied in rat brain preparations. Clozapine N-oxide was the major metabolic pathway in rat brain.
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页码：109 / 114
页数：5
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