A novel long-chain acyl-derivative of epigallocatechin-3-O-gallate prepared and purified from green tea polyphenols

被引：0
作者：
Chen Ping
Tan Yao
Sun Dong
Zheng Xiao-ming
机构：
[1] Zhejiang University,Catalysis Institute
[2] Medical College of Wenzhou,undefined
来源：
Journal of Zhejiang University-SCIENCE A | 2003年 / 4卷 / 6期
关键词：
Green tea polyphenols; Lipophilic tea polyphenols; Epigallocatechin-3-; -gallate; Epigallocatechin-3-; -gallate-4′-; -hexadecanate; Isolation; High-speed countercurrent chromatography; A; O69; S571.1;
D O I：
10.1631/BF02851613
中图分类号：
学科分类号：
摘要：
Lipophilic tea polyphenols (LTP) were prepared by catalytic esterification of green tea polyphenols (GTP) with hexadecanoyl chloride. A novel long-chain acyl-derivative of epigallocatechin-3-o-gallate (EGCG) was first isolated from purification of LTP by high-speed countercurrent chromatography (HSCCC) using a solvent system composed of n-hexane-ethyl acetate-methanol-water (1∶1∶1∶1, v/v). The molecular structure of the acyl-derivative, Epigallocatechin-3-O-gallate-4′-O-hexadecanate, was elucidated by means of elemental analysis, IR,1H-NMR and MS spectra.
引用
收藏
页码：714 / 718
页数：4
相关论文
共 40 条
  • [1] Dreosti I. E.(1996)Bioactive ingredients: antioxidants and polyphenols in tea Nutr. Rev. 54 S51-S58
  • [2] Hollman P. C. H.(1999)Tea falvonols in cardiovascular disease and cancer epidemiology Proc. Soc. Exp. Biol. Med. 220 198-202
  • [3] Feskens E. J. M.(1998)2D NMR study on tea polyphenols Chin. J. Mag. Resonance 15 23-30
  • [4] Katan M. B.(2000)Effects of epigallocatechin gallate and quercetin on oxidative damage to cellular DNA Mutat. Res. 459 211-218
  • [5] Jia Z. S.(2000)Green tea polyphenols induce apoptosis in vitro in peripheral blood T lymphocytes of adult T-cell leukemia patients Jpn. J. Cancer. Res. 91 34-40
  • [6] Zhou B.(1999)Antioxidant properties of lipophilic tea polyphenols J. Zhejiang University (Agric. & Life Sci.) 25 529-534
  • [7] Yang L.(1991)Systematic search for suitable two-phase solvent systems for high-speed counter-current chromatography J. Chromatogr. 538 99-108
  • [8] Wu L. M.(2002)Synthesis of liposoluble tea polyphenols with varying aliphatic groups and their antioxidarion activity Chin. Fine Chemicals 19 86-89
  • [9] Liu Z. L.(2001)Identification of reaction products of (−)-epigallocatechin, (−)-epigallocatechin gallate and pyrogallol with 2,2-diphenyl-1-picrylhydrazyl radical Food Chemistry 73 345-349
  • [10] Johnson M. K.(undefined)undefined undefined undefined undefined-undefined
1234