Hemolytic uremic syndrome following prolonged gemcitabine therapy: report of four cases from a single institution

被引：0
作者：
S. Müller
P. Schütt
P. Bojko
M. R. Nowrousian
J. Hense
S. Seeber
T. Moritz
机构：
[1] University of Duisburg-Essen Medical School,Department of Internal Medicine (Cancer Research), West German Cancer Center
来源：
Annals of Hematology | 2005年 / 84卷
关键词：
Hemolytic uremic syndrome; Hemolysis; Gemcitabine; Thrombocytopenia; Renal failure; Microangiopathic thrombotic disease;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Hemolytic uremic syndrome (HUS) has been described following the administration of multiple antineoplastic agents, most notably mitomycin C. More recently, several cases of gemcitabine-induced HUS have been observed with the overall incidence of gemcitabine-induced HUS estimated at 0.015–0.25%. We here report on four patients who developed HUS following gemcitabine therapy at our institution within the last year (incidence 1.4%). All these patients had advanced-stage disease, were heavily pretreated, and received prolonged gemcitabine application, suggesting that in this subgroup of patients HUS may be more frequently encountered than documented so far.
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页码：110 / 114
页数：4
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