Clinical implications of the innate and adaptive immune response to HBV and HCV

被引：0
作者：
Suong T. Le
Kumar Visvanathan
机构：
[1] Department of Gastroenterology, Southern Health, Clayton, VIC, Clayton Rd
[2] Department of Infectious Diseases, Southern Health, Clayton, VIC, Clayton Rd
[3] Department of Medicine, Monash University (MMC), Clayton, VIC, Clayton Rd
[4] Department of Infectious Diseases, Monash Medical Centre, Clayton, VIC, Clayton Rd
来源：
Current Hepatitis Reports | 2012年 / 11卷 / 4期
关键词：
Natural killer cells; Pattern recognition receptors; T lymphocytes; TRAIL;
D O I：
10.1007/s11901-012-0145-3
中图分类号：
学科分类号：
摘要：
The tolerogenicity of the liver renders it vulnerable to hepatotrophic pathogens such as hepatitis B virus (HBV) and hepatitis C virus (HCV). Both viruses have successfully co-evolved within the human host by evading and counteracting immune control. Inadequate cell culture and animal models have limited definitive characterization of the immunological mechanisms arbitrating virus and host co-existence. The clinical sequelae of chronic viral hepatitis such as cirrhosis and hepatocellular carcinoma are not directly mediated by the viruses but rather by hepatotoxic immunological mediators and cytokines. The pro-fibrotic T helper 2 (Th2) response promoted by this altered cytokine milieu is associated with viral persistence. In this chapter, the innate and adaptive immune response to acute and chronic HBV and HCV is reviewed with particular focus on its clinical implications. © Springer Science+Business Media New York 2012.
引用
收藏
页码：243 / 249
页数：6
相关论文
共 52 条
[1]  
Racanelli V., Rehermann B., The Liver as an Immunological Organ, Hepatology, 43, (2006)
[2]  
Saito T., Et al., Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA, Nature, 454, 7203, pp. 523-527, (2008)
[3]  
Lee M., Kim Y.-J., Signaling pathways downstream of patternrecognition receptors and their cross talk, Annu Rev Biochem, 76, pp. 447-480, (2007)
[4]  
Coudert J.D., Et al., Altered NKG2D function in NK cells induced by chronic exposure to NKG2D ligand-expressing tumor cells, Blood, 106, pp. 1711-1717, (2005)
[5]  
Oppenheim D.E., Et al., Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immunosurveillance, Nat Immunol, 6, pp. 928-937, (2005)
[6]  
Olviero B., Natural Killer cell functional dichotomy in chronic hepatitis B and chronic hepatitis C virus infections, Gastroenterology, 137, pp. 1151-1160, (2009)
[7]  
Dunn C., Et al., Temporal analysis of early immune responses in patients with acute hepatitis B virus infection, Gastroenterology, 137, pp. 1289-1300, (2009)
[8]  
Wieland S., Et al., Genomic analysis of early immune responses in patients with acute hepatitis B virus infection, Proc Natl Acad Sci U S A, 101, pp. 66669-66674, (2004)
[9]  
Bertoletti A., Ferrari C., Innate and adaptive immune responses in chronic hepatitis B virus infections: Towards restoration of immune control of viral infection, Gut, (2011)
[10]  
Fisicaro P., Et al., Early kinetics of innate and adaptive immune responses during hepatitis B virus infection, Gut, 58, pp. 974-982, (2009)
123456