Chimeric provirus of bovine leukemia virus/SMAD family member 3 in cattle with enzootic bovine leukosis

被引：0
作者：
Naganori Nao
Tomohiro Okagawa
Naomi Nojiri
Satoru Konnai
Honami Shimakura
Misono Tominaga
Hazuka Yoshida-Furihata
Eri Nishiyama
Takahiro Matsudaira
Naoya Maekawa
Shiro Murata
Masamichi Muramatsu
Kazuhiko Ohashi
Masumichi Saito
机构：
[1] Hokkaido University,Division of International Research Promotion, International Institute for Zoonosis Control
[2] Hokkaido University,One Health Research Center
[3] Hokkaido University,Institute for Vaccine Research and Development (IVReD)
[4] Hokkaido University,Department of Advanced Pharmaceutics, Faculty of Veterinary Medicine
[5] National Institute of Infectious Diseases,Center for Emergency Preparedness and Response
[6] Hokkaido University,Department of Disease Control, Faculty of Veterinary Medicine
[7] FASMAC Co.,Biotechnological Research Support Division
[8] Ltd,Department of Virology II
[9] National Institute of Infectious Diseases,undefined
来源：
Archives of Virology | 2024年 / 169卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Bovine leukemia virus (BLV) is a member of the family Retroviridae that causes enzootic bovine leukemia (EBL). However, the association between BLV infection and EBL development remains unclear. In this study, we identified a BLV/SMAD3 chimeric provirus within CC2D2A intron 30 in monoclonal expanded malignant cells from a cow with EBL. The chimeric provirus harbored a spliced SMAD3 sequence composed of exons 3–9, encoding the short isoform protein, and the BLV-SMAD3 chimeric transcript was detectable in cattle with EBL. This is the first report of a BLV chimeric provirus that might be involved in EBL tumorigenesis.
引用
收藏
相关论文
共 50 条
[21]   Circulating Cell-Free DNA of Bovine Leukemia Virus: A Promising Biomarker for Enzootic Bovine Leukosis [J].
Jahan, M. Ishrat ;
Inenaga, Toshiaki ;
Makimoto, Sakurako ;
Hossain, Md. Belal ;
Matsuoka, Yuka ;
Sithi, Sharmin Nahar ;
Rajib, Samiul Alam ;
Ansori, Arif Nur Muhammad ;
Sugata, Kenji ;
Imakawa, Kazuhiko ;
Kobayashi, Tomoko ;
Satou, Yorifumi .
MICROBIOLOGY AND IMMUNOLOGY, 2025,
[22]   BOVINE LEUKEMIA-VIRUS RIBONUCLEIC INFORMATION IN CULTURED VIRUS-PRODUCING CELLS AND IN TUMORS AND CIRCULATING LYMPHOCYTES OF CATTLE AFFECTED BY ENZOOTIC BOVINE LEUKOSIS [J].
MARBAIX, G ;
KETTMANN, R ;
CLEUTER, Y ;
BURNY, A .
ARCHIVES INTERNATIONALES DE PHYSIOLOGIE DE BIOCHIMIE ET DE BIOPHYSIQUE, 1980, 88 (04) :B170-B171
[23]   GENOMIC INTEGRATION OF BOVINE LEUKEMIA PROVIRUS - COMPARISON BETWEEN PERSISTENT LYMPHOCYTOSIS AND LYMPH-NODE TUMOR FORM OF ENZOOTIC BOVINE LEUKOSIS [J].
KETTMANN, R ;
CLEUTER, Y ;
MAMMERICKX, M ;
BURNY, A .
ARCHIVES INTERNATIONALES DE PHYSIOLOGIE DE BIOCHIMIE ET DE BIOPHYSIQUE, 1980, 88 (03) :B139-B139
[24]   ENZOOTIC BOVINE LEUKOSIS - A SLOW VIRUS-DISEASE [J].
STRAUB, OC .
OUTLOOK ON AGRICULTURE, 1984, 13 (04) :179-184
[25]   Serological evidence of the occurrence of enzootic bovine leukosis (EBL) virus infection in cattle in Tanzania [J].
Schoepf, KC ;
Kapaga, AM ;
Msami, HM ;
Hyera, JMK .
TROPICAL ANIMAL HEALTH AND PRODUCTION, 1997, 29 (01) :15-19
[26]   MILK AS SUBSTRATE FOR THE DIAGNOSIS OF ENZOOTIC BOVINE LEUKOSIS (EBL) OF CATTLE [J].
MANZ, D .
DEUTSCHE TIERARZTLICHE WOCHENSCHRIFT, 1981, 88 (05) :169-171
[27]   IMMUNOHISTOLOGIC STUDIES ON SUBPOPULATIONS OF LYMPHOCYTES IN CATTLE WITH ENZOOTIC BOVINE LEUKOSIS [J].
CHIBA, T ;
HIRAGA, M ;
AIDA, Y ;
AJITO, T ;
ASAHINA, M ;
WU, D ;
OHSHIMA, K ;
DAVIS, WC ;
OKADA, K .
VETERINARY PATHOLOGY, 1995, 32 (05) :513-520
[28]   SEROLOGICAL AND HEMATOLOGICAL DIAGNOSIS OF ENZOOTIC BOVINE LEUKOSIS IN CATTLE IN TURKEY [J].
BATMAZ, H ;
CARLI, KT ;
KAHRAMAN, M ;
CETIN, C ;
KENNERMAN, E .
VETERINARY RECORD, 1995, 136 (02) :42-44
[29]   Epidemiological evidence for early-onset of enzootic bovine leukosis by L233-Tax- carrying bovine leukemia virus in Japanese Black cattle [J].
Tomiyasu, Takafumi ;
Mori, Hiroshi ;
Okazaki, Katsunori .
JOURNAL OF VETERINARY MEDICAL SCIENCE, 2022, 84 (09) :1216-1220
[30]   Delayed-onset enzootic bovine leukosis possibly caused by superinfection with bovine leukemia virus mutated in the pol gene [J].
Tadaaki Watanabe ;
Emi Inoue ;
Hiroshi Mori ;
Yoshiaki Osawa ;
Katsunori Okazaki .
Archives of Virology, 2015, 160 :2087-2091
12345