Chimeric provirus of bovine leukemia virus/SMAD family member 3 in cattle with enzootic bovine leukosis

被引：0

作者：

Naganori Nao

Tomohiro Okagawa

Naomi Nojiri

Satoru Konnai

Honami Shimakura

Misono Tominaga

Hazuka Yoshida-Furihata

Eri Nishiyama

Takahiro Matsudaira

Naoya Maekawa

Shiro Murata

Masamichi Muramatsu

Kazuhiko Ohashi

Masumichi Saito

机构：

[1] Hokkaido University,Division of International Research Promotion, International Institute for Zoonosis Control

[2] Hokkaido University,One Health Research Center

[3] Hokkaido University,Institute for Vaccine Research and Development (IVReD)

[4] Hokkaido University,Department of Advanced Pharmaceutics, Faculty of Veterinary Medicine

[5] National Institute of Infectious Diseases,Center for Emergency Preparedness and Response

[6] Hokkaido University,Department of Disease Control, Faculty of Veterinary Medicine

[7] FASMAC Co.,Biotechnological Research Support Division

[8] Ltd,Department of Virology II

[9] National Institute of Infectious Diseases,undefined

来源：

Archives of Virology | 2024年 / 169卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Bovine leukemia virus (BLV) is a member of the family Retroviridae that causes enzootic bovine leukemia (EBL). However, the association between BLV infection and EBL development remains unclear. In this study, we identified a BLV/SMAD3 chimeric provirus within CC2D2A intron 30 in monoclonal expanded malignant cells from a cow with EBL. The chimeric provirus harbored a spliced SMAD3 sequence composed of exons 3–9, encoding the short isoform protein, and the BLV-SMAD3 chimeric transcript was detectable in cattle with EBL. This is the first report of a BLV chimeric provirus that might be involved in EBL tumorigenesis.

引用

共 50 条

[21] BOVINE LEUKEMIA-VIRUS RIBONUCLEIC INFORMATION IN CULTURED VIRUS-PRODUCING CELLS AND IN TUMORS AND CIRCULATING LYMPHOCYTES OF CATTLE AFFECTED BY ENZOOTIC BOVINE LEUKOSIS
MARBAIX, G
KETTMANN, R
CLEUTER, Y
BURNY, A
ARCHIVES INTERNATIONALES DE PHYSIOLOGIE DE BIOCHIMIE ET DE BIOPHYSIQUE, 1980, 88 (04): : B170 - B171
[22] GENOMIC INTEGRATION OF BOVINE LEUKEMIA PROVIRUS - COMPARISON BETWEEN PERSISTENT LYMPHOCYTOSIS AND LYMPH-NODE TUMOR FORM OF ENZOOTIC BOVINE LEUKOSIS
KETTMANN, R
CLEUTER, Y
MAMMERICKX, M
BURNY, A
ARCHIVES INTERNATIONALES DE PHYSIOLOGIE DE BIOCHIMIE ET DE BIOPHYSIQUE, 1980, 88 (03): : B139 - B139
[23] ENZOOTIC BOVINE LEUKOSIS - A SLOW VIRUS-DISEASE
STRAUB, OC
OUTLOOK ON AGRICULTURE, 1984, 13 (04) : 179 - 184
[24] Serological evidence of the occurrence of enzootic bovine leukosis (EBL) virus infection in cattle in Tanzania
Schoepf, KC
Kapaga, AM
Msami, HM
Hyera, JMK
TROPICAL ANIMAL HEALTH AND PRODUCTION, 1997, 29 (01) : 15 - 19
[25] MILK AS SUBSTRATE FOR THE DIAGNOSIS OF ENZOOTIC BOVINE LEUKOSIS (EBL) OF CATTLE
MANZ, D
DEUTSCHE TIERARZTLICHE WOCHENSCHRIFT, 1981, 88 (05): : 169 - 171
[26] SEROLOGICAL AND HEMATOLOGICAL DIAGNOSIS OF ENZOOTIC BOVINE LEUKOSIS IN CATTLE IN TURKEY
BATMAZ, H
CARLI, KT
KAHRAMAN, M
CETIN, C
KENNERMAN, E
VETERINARY RECORD, 1995, 136 (02) : 42 - 44
[27] IMMUNOHISTOLOGIC STUDIES ON SUBPOPULATIONS OF LYMPHOCYTES IN CATTLE WITH ENZOOTIC BOVINE LEUKOSIS
CHIBA, T
HIRAGA, M
AIDA, Y
AJITO, T
ASAHINA, M
WU, D
OHSHIMA, K
DAVIS, WC
OKADA, K
VETERINARY PATHOLOGY, 1995, 32 (05) : 513 - 520
[28] Epidemiological evidence for early-onset of enzootic bovine leukosis by L233-Tax- carrying bovine leukemia virus in Japanese Black cattle
Tomiyasu, Takafumi
Mori, Hiroshi
Okazaki, Katsunori
JOURNAL OF VETERINARY MEDICAL SCIENCE, 2022, 84 (09) : 1216 - 1220
[29] Delayed-onset enzootic bovine leukosis possibly caused by superinfection with bovine leukemia virus mutated in the pol gene
Tadaaki Watanabe
Emi Inoue
Hiroshi Mori
Yoshiaki Osawa
Katsunori Okazaki
Archives of Virology, 2015, 160 : 2087 - 2091
[30] EXPERIMENTAL-INFECTION OF LAMBS WITH VIRUS OF ENZOOTIC BOVINE LEUKOSIS
GRUNDBOECK, M
GRUNDBOECKJUSKO, J
RULKA, J
SCOTKA, M
ARCHIV FUR EXPERIMENTELLE VETERINARMEDIZIN, 1986, 40 (03): : 356 - 362

← 1 2 3 4 5 →