Piperine Augments the Protective Effect of Curcumin Against Lipopolysaccharide-Induced Neurobehavioral and Neurochemical Deficits in Mice

被引:0
|
作者
Ashok Jangra
Mohit Kwatra
Tavleen Singh
Rajat Pant
Pawan Kushwah
Yogita Sharma
Babita Saroha
Ashok Kumar Datusalia
Babul Kumar Bezbaruah
机构
[1] Laboratory of Neuroscience,Department of Pharmacology and Toxicology
[2] National Institute of Pharmaceutical Education and Research,Department of Biotechnology
[3] University Institute of Engineering & Technology (UIET),Department of Pharmacology
[4] Maharishi Dayanand University,undefined
[5] National Brain Research Centre,undefined
[6] Gauhati Medical College,undefined
来源
Inflammation | 2016年 / 39卷
关键词
depression; anxiety; curcumin; piperine; oxido-nitrostative stress;
D O I
暂无
中图分类号
学科分类号
摘要
The aim of the present study was to investigate the protective effects of curcumin alone and in combination with piperine against lipopolysaccharide (LPS)-induced neurobehavioral and neurochemical deficits in the mice hippocampus. Mice were treated with curcumin (100, 200, and 400 mg/kg, p.o.) and piperine (20 mg/kg, p.o.) for 7 days followed by LPS (0.83 mg/kg, i.p.) administration. Animals exhibited anxiety and depressive-like phenotype after 3 and 24 h of LPS exposure, respectively. LPS administration increased the oxido-nitrosative stress as evident by elevated levels of malondialdehyde, nitrite, and depletion of glutathione level in the hippocampus. Furthermore, we found raised level of pro-inflammatory cytokines (IL-1β and TNF-α) in the hippocampus of LPS-treated mice. Pretreatment with curcumin alleviated LPS-induced neurobehavioral and neurochemical deficits. Furthermore, co-administration of curcumin with piperine significantly potentiated the neuroprotective effect of curcumin. These results demonstrate that piperine enhanced the neuroprotective effect of curcumin against LPS-induced neurobehavioral and neurochemical deficits.
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页码:1025 / 1038
页数:13
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