The Diagnostic Potential of Monoclonal Antibodies to Adenovirus

被引：0
作者：
T. A. Timoshicheva
I. V. Amosova
M. P. Grudinin
机构：
[1] Smorodintsev Research Institute of Influenza,
[2] Ministry of Health of the Russian Federation,undefined
来源：
Applied Biochemistry and Microbiology | 2022年 / 58卷
关键词：
monoclonal antibodies; human adenovirus; adenovirus infection; diagnosis;
D O I：
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摘要：
The diagnostic potential of the 4B7 and 6B12 monoclonal antibodies (MAbs) against human adenovirus hexon protein has been studied in various immunological tests, namely, the in-cell enzyme-linked immunosorbent assay (cell-ELISA), sandwich ELISA, and the immunofluorescence antibody technique (IFA). It was shown that the sensitivities of cell-ELISA, sandwich ELISA, and IFA were 96, 86, and 84%, respectively, compared to PCR. Thus, 4B7 and 6B12 MAbs are promising immunoreagents for the construction of various diagnostic kits to use in laboratory practice for adenovirus detection in clinical samples.
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页码：873 / 877
页数：4
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