Differential MicroRNA Expression Profiles as Potential Biomarkers for Pancreatic Ductal Adenocarcinoma

被引：0
作者：
Y. Zhu
J. Wang
F. Wang
Z. Yan
G. Liu
Y. Ma
W. Zhu
Y. Li
L. Xie
A. V. Bazhin
X. Guo
机构：
[1] Henan University Huaihe Hospital,Department of Oncology, International Joint Laboratory for Cell Medical Engineering of Henan Province
[2] The Second Affiliated Hospital of Zhengzhou University,Department of Oncology
[3] Henan University,Department of Preventive Medicine, Cell Signal Transduction Laboratory, Joint National Laboratory for Antibody Drug Engineering, Institute of Biomedical Informatics, Medical School
[4] Nankai University,College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research
[5] Stanford University,Department of Anesthesia
[6] Ludwig-Maximilians-University Munich,Department of General, Visceral, and Transplantation Surgery
来源：
Biochemistry (Moscow) | 2019年 / 84卷
关键词：
pancreatic ductal adenocarcinoma; plasma miRNA; expression profiling;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Pancreatic ductal adenocarcinoma (PDAC) remains a clinical challenge due to its poor prognosis. Therefore, the early diagnosis of PDAC is extremely important for achieving a cure. MicroRNAs (miRNAs) could serve as a potential bio-marker for the early detection and prognosis of PDAC. In this work we analyzed plasma samples from healthy persons and PDAC patients to assess differential miRNA expression profiles by next generation sequencing technology and bioinformatics analysis. In this way, 165 mature miRNAs were found to be significantly deregulated in the patient group, of which 75 and 90 mature miRNAs were up- and down-regulated compared with healthy individuals, respectively. Furthermore, 1029 novel miRNAs were identified. In conclusion, plasma miRNA expression profiles are different between healthy individuals and patients with PDAC. These data provide a possibility for use of miRNA as diagnostic and prognostic biomarkers of PDAC.
引用
收藏
页码：575 / 582
页数：7
相关论文
共 353 条
[1]  
Raimondi S(2009)Epidemiology of pancreatic cancer: an overview Nat. Rev. Gastroenterol. Hepatol. 6 699-708
[2]  
Maisonneuve P(2013)Improvement of surgical results for pancreatic cancer Lancet Oncol. 14 476-485
[3]  
Lowenfels A B(1993)The Cell 75 843-854
[4]  
Hartwig W(2010) heterochronic gene Nat. Rev. Genet. 11 597-610
[5]  
Werner J(2011) encodes small RNAs with antisense complementarity to Nat. Rev. Cancer 11 644-656
[6]  
Jager D(2007)The wide-spread regulation of microRNA biogenesis, function and decay Nat. Rev. Mol. Cell Biol. 8 23-36
[7]  
Debus J(2008)MicroRNA regulation by RNA-binding proteins and its implications for cancer Nat. Rev. Mol. Cell Biol. 9 219-230
[8]  
Buchler M W(2011)Illuminating the silence: understanding the structure and function of small RNAs Mol. Cell 44 424-436
[9]  
Lee R C(2006)Small non-coding RNAs in animal development Nat. Rev. Cancer 6 259-269
[10]  
Feinbaum R L(2017)MCPIP1 ribonuclease antagonizes dicer and terminates microRNA biogenesis through precursor microRNA degradation Acta Pharm. Sin. B 7 38-51
12345678910