Potential therapeutic efficacy of a bactericidal–immunomodulatory fusion peptide against methicillin-resistant Staphylococcus aureus skin infection

被引：5
作者：
Qingtian Li
Yuhua Zhou
Ke Dong
Xiaokui Guo
机构：
[1] Shanghai Jiao Tong University School of Medicine,Department of Medical Microbiology and Parasitology, Institutes of Medical Sciences
[2] Shanghai Jiao Tong University School of Medicine,Department of Medical Microbiology and Parasitology
来源：
Applied Microbiology and Biotechnology | 2010年 / 86卷
关键词：
Fusion peptide; MRSA; Antimicrobial peptide; Human ß-defensin 3;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
To enhance the potential therapeutic efficacy of an antimicrobial peptide human β-defensin 3, two fusion peptides, a bactericidal–immunomodulatory fusion peptide human β-defensin 3-mannose-binding lectin and a bactericidal–bactericidal fusion peptide human β-defensin 3-lysozyme were synthesized and the bactericidal activities in vitro and in vivo against methicillin-resistant Staphylococcus aureus N315 were demonstrated in this study. Peptide human β-defensin 3-lysozyme showed the best bactericidal activity in vitro, but human β-defensin 3-mannose-binding lectin showed a significant improvement in angiogenesis and tissue reconstruction. Our results illustrated that outstanding bactericidal activity in vitro is not essential in the development of antimicrobial peptides. Fusion strategy and immunomodulatory factors should be utilized in novel antimicrobial peptide development.
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页码：305 / 309
页数：4
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