Pyroptosis, a target for cancer treatment?

被引:0
作者
Ying Huang
Jian-Wei Wang
Jiao Huang
Lu Tang
Yun-Hua Xu
Hong Sun
Jie Tang
Guo Wang
机构
[1] Central South University,Department of Clinical Pharmacology, Xiangya Hospital
[2] Central South University,Institute of Clinical Pharmacology
[3] Hunan Key Laboratory of Pharmacogenetics,Engineering Research Center of Applied Technology of Pharmacogenomics
[4] Ministry of Education,Department of Thoracic Surgery
[5] National Clinical Research Center for Geriatric Disorders,Institute of Clinical Medicine of the First Affiliated Hospital
[6] Guangdong Xiangxue Life Sciences,Institute for Inheritance
[7] Ltd,Based Innovation of Chinese Medicine, School of Pharmaceutical Science, Health Science Center
[8] Xiangya Hospital,Department of Pharmacy
[9] University of South China,undefined
[10] Shenzhen University,undefined
[11] Fujian Provincial Hospital,undefined
[12] Shengli Clinical Medical College of Fujian Medical University,undefined
来源
Apoptosis | 2022年 / 27卷
关键词
Pyroptosis; Immunity; Cancer; Chemotherapy sensitivity; Cancer treatment;
D O I
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中图分类号
学科分类号
摘要
Pyroptosis is a newly discovered form of programmed cell death mediated by the gasdermin protein, that is accompanied by inflammation and immune response. A growing body of evidence suggests that pyroptosis is closely related to cancer, and it is becoming a new cancer research topic. Studies have suggested that different cancer cells activate pyroptosis in different ways and that the effects of pyroptosis vary in different cancer backgrounds. In this article, we briefly introduce the definition, characteristics, and activation pathways of pyroptosis. Then we review the complex effects of pyroptosis on cancer development, which generally include inhibition of cancer cell viability, impacts on the invasion and migration of cancer cells, improvement of antitumor immunity, and enhancement of chemotherapy sensitivity. We also discuss drugs and compounds that can induce pyroptosis, as well as the interaction between pyroptosis and apoptosis. Elucidating the mechanisms of the complex effects of pyroptosis is likely to pave the way for therapeutic approaches for cancer in the future.
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页码:1 / 13
页数:12
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