Bacterial vaginosis and human immunodeficiency virus infection

被引：46
作者：
Spear G.T. [1 ]
St. John E. [1 ]
Reza M.R. [1 ]
机构：
[1] Department of Immunology/Microbiology, Rush University Medical Center, Chicago
来源：
AIDS Research and Therapy | / 4卷 / 1期
关键词：
Lactobacillus; Sexually Transmitted Infection; Genital Tract; Bacterial Vaginosis; Vaginal Fluid;
D O I：
10.1186/1742-6405-4-25
中图分类号：
学科分类号：
摘要：
Epidemiologic studies indicate that bacterial vaginosis (BV), a common alteration of lower genital tract flora in women, is associated with increased susceptibility to HIV infection. Other recent studies show that HIV is detected more frequently and at higher levels in the lower genital tract of HIV-seropositive women with BV. In vitro studies show that genital tract secretions from women with BV or flora associated with BV induce HIV expression in infected cells. The increased HIV expression appears to be due at least in part to activation through Toll-like receptors (TLR), specifically TLR2. Further research is needed to elucidate how BV contributes to HIV acquisition and transmission. © 2007 Spear et al; licensee BioMed Central Ltd.
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