Two New Anti-Tobacco Mosaic Virus Quinoline Alkaloids from the Stems of Nicotiana tabacum

被引：0
作者：
Le-Le Deng
Wen-Wu Yang
Jia-Rui Jiang
Li Xu
Jian-Duo Zhang
Chun-Bo Liu
Jun Ling
Wei-Song Kong
Xue-Mei Li
Yin-Ke Li
Xin Liu
Tao Zhou
机构：
[1] China Tobacco Yunnan Industrial Co.,Technology Center
[2] Ltd.,Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education
[3] Yunnan Minzu University,undefined
来源：
Chemistry of Natural Compounds | 2022年 / 58卷
关键词：
quinoline alkaloids; anti-tobacco mosaic virus activity;
D O I：
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中图分类号：
学科分类号：
摘要：
Two new quinoline alkaloids, 4-acetyl-7-isopropyl-6-methylquinolin-2(1H)-one (1) and 4-acetyl-7-isopropyl-5-methylquinolin-2(1H)-one (2), were isolated from the stems of Nicotiana tabacum. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1 and 2 were tested for their anti-tobacco mosaic virus (anti-TMV) activity. The results showed that compounds 1 and 2 exhibited high anti-TMV activity with inhibition rates of 38.5 and 42.2% at the concentration of 20 μM, respectively. These rates are higher than that of positive control.
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页码：78 / 81
页数：3
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