Synthesis, structure–activity relationship and antinociceptive activities of some 2-(2′-pyridyl) benzimidazole derivatives

被引：0
作者：
Arfa Kamil
Shamim Akhtar
Ajmal Khan
Erum Farooq
Umar Nishan
Reaz Uddin
Umar Farooq
机构：
[1] Federal Urdu University of Arts,Department of Pharmaceutical Chemistry, Faculty of Pharmacy
[2] Science and Technology,Department of Pharmaceutical Chemistry, Faculty of Pharmacy
[3] Karachi,Department of Chemistry
[4] University of Karachi,Interdisciplinary Research Centre in Biomedical Materials (IRCBM)
[5] COMSATS Institute of Information Technology,Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences
[6] COMSATS Institute of Information Technology,undefined
[7] University of Karachi,undefined
来源：
Medicinal Chemistry Research | 2016年 / 25卷
关键词：
2-(2′-Pyridyl) benzimidazole; Analgesic activities; Spectroscopic techniques; Mass spectroscopy; Elemental analysis; Analgesic activity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In the present study, a new series of 2-(2′-pyridyl) benzimidazole derivatives 1–11 were resynthesized and evaluated for analgesic activity. The 2-(2′-pyridyl) benzimidazole was quaternized at its nitrogen atom in the ring with various substituted and unsubstituted phenacyl halides. As a result, eleven novel derivatives were synthesized. The structures of these new synthetic derivatives of 2-(2′-pyridyl) benzimidazole were confirmed by using different spectroscopic techniques i.e., UV/Visible, IR, 1HNMR and Mass spectroscopy. Percentage of carbon, hydrogen and nitrogen was also determined by elemental analysis. All the synthetic compounds showed significant analgesic activity with dose-dependent manner.
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页码：1216 / 1228
页数：12
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