Contribution of neural crest-derived stem cells and nasal chondrocytes to articular cartilage regeneration

被引：0
作者：
Tianyou Li
Song Chen
Ming Pei
机构：
[1] West Virginia University,Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics
[2] Shandong Provincial Hospital affiliated to Shandong First Medical University,Department of Pediatric Orthopaedics
[3] The General Hospital of Western Theater Command,Department of Orthopaedics
[4] West Virginia University,WVU Cancer Institute, Robert C. Byrd Health Sciences Center
来源：
Cellular and Molecular Life Sciences | 2020年 / 77卷
关键词：
Neural crest-derived cells; Mesoderm-derived cells; Cartilage regeneration; Stem cells; Nasal chondrocytes; Articular chondrocytes;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Due to poor self-regenerative potential of articular cartilage, stem cell-based regeneration becomes a hopeful approach for the treatment of articular cartilage defects. Recent studies indicate that neural crest-derived cells (NCDCs) have the potential for repairing articular cartilage with even greater chondrogenic capacity than mesoderm-derived cells (MDCs): a conventional stem cell source for cartilage regeneration. Given that NCDCs originate from a different germ layer in the early embryo compared with MDCs that give rise to articular cartilage, a mystery remains regarding their capacity for articular cartilage regeneration. In this review, we summarize the similarities and differences between MDCs and NCDCs including articular and nasal chondrocytes in cell origin, anatomy, and chondrogenic differentiation and propose that NCDCs might be promising cell origins for articular cartilage regeneration.
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页码：4847 / 4859
页数：12
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