Intrinsically disordered proteins in cellular signalling and regulation

Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) of proteins that may also contain structured domains mediate crucial signalling processes in eukaryotic cells.Disorder is advantageous in cell signalling because disordered sequences have the potential to bind to multiple partners, often using different structures.Disordered regions are relatively accessible, often contain multiple binding motifs and are frequently the sites for post-translational modification, an important mediator of the control of signalling pathways.Disordered proteins have central roles in the formation of higher-order signalling assemblies and in the operation of circadian clocks.