The Gonadotropin-Releasing Hormone Type I Receptor is Expressed in the Mouse Cerebellum

Gonadotropin-releasing hormone (GnRH) is a decapeptide hypothalamic hormone that was named according to its first discovered function—at the head of the neuroendocrine reproductive axis. Numerous other organ systems express GnRH and/or its receptor, although a specific physiological role for GnRH outside of the reproductive axis has yet to be established. Several studies in lower vertebrates have reported GnRH and/or its receptor in the cerebellum. Here, we describe the presence of immunoreactive GnRH receptors in the Purkinje cells of the mammalian cerebellum for the first time. This study provides compelling anatomical evidence for a common link between the cerebellum and the hypothalamo–pituitary axis. Dysfunction of this link occurs in the rare genetic ataxia disorders—Gordon Holmes syndrome and Boucher–Neuhauser syndrome.