Lumbar spondylolysis and spondylolisthesis in down syndrome: A cross-sectional study at one institution

被引：3
作者：
Hansdorfer M.A. [1 ]
Mardjetko S.M. [1 ]
Knott P.T. [2 ]
Thompson S.E. [1 ]
机构：
[1] Illinois Bone and Joint Institute, Morton Grove, IL 60053
[2] College of Health Professions, Rosalind Franklin University, North Chicago, IL 60064
来源：
Spine Deformity | 2013年 / 1卷 / 5期
关键词：
Down syndrome; Low back pain; Spondylolisthesis; Spondylolysis;
D O I：
10.1016/j.jspd.2013.05.011
中图分类号：
学科分类号：
摘要：
Study Design: Retrospective cross-sectional study. Objectives To describe lumbar spondylolysis and spondylolisthesis and establish their prevalence in individuals with Down syndrome. Summary of Background Data: Orthopedic problems in Down syndrome are variable and numerous. Lumbar spondylolysis and spondylolisthesis may be common conditions in Down syndrome. However, there has been a paucity of data on the association of these conditions in the published literature. Methods: A retrospective review of 110 patients with Down syndrome seen at a single institution from 2000 through 2012 was performed. Medical records, X-rays, and physician dictations were carefully reviewed to establish a detailed database of the study population. Results: Of the 110 patients in the study, 20 exhibited spondylolysis (unilateral, n = 11; bilateral, n = 9), whereas 38 had lumbar spondylolisthesis (isthmic, n = 9; dysplastic, n = 2; degenerative, n = 27). No gender difference was noted (p ≥.7732). Fifteen patients reported low back pain (LBP) and/or leg pain. There was no significant association between LBP, leg pain, and spondylolysis (p =.9232). Both of these symptoms were highly predictive of lumbar spondylolisthesis, however (p =.0006). No significant findings were noted in pelvic parameters (pelvic incidence, sacral slope, pelvic tilt, or lumbar lordosis) in this study. Conclusions: The prevalence of spondylolysis and spondylolisthesis in individuals with Down syndrome may be as high as 18.7% and 32.7%, respectively, significantly higher than in the non-Downs population. Etiopathogenesis of these conditions in Down syndrome does not appear to be related to pelvic parameters. Low back pain and leg pain may be more predictive of spondylolisthesis in Down syndrome than in the general population. Therefore, it is recommended that individuals with Down syndrome and LBP and/or leg pain be evaluated for lumbar spondylolisthesis. © 2013 Scoliosis Research Society.
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页码：382 / 388
页数：6
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