Immunohistochemical localization of anterior pituitary hormones in S-100 protein-positive cells in the rat pituitary gland

被引:0
作者
Motoshi Kikuchi
Megumi Yatabe
Yukiko Tando
Takashi Yashiro
机构
[1] Jichi Medical University School of Medicine,Laboratory of Education
[2] Jichi Medical University School of Medicine,Division of Histology, Department of Anatomy
来源
Cell and Tissue Research | 2011年 / 345卷
关键词
S-100 protein; Pituitary hormone; Folliculo-stellate cell; Pituitary; Intermediate lobe;
D O I
暂无
中图分类号
学科分类号
摘要
In the anterior and intermediate lobes of the rat pituitary gland, non-hormone-producing cells that express S-100 protein coexist with various types of hormone-producing cells and are believed to function as phagocytes, supporting and paracrine-controlling cells of hormone-producing cells and stem cells, among other functions; however, their cytological characteristics are not yet fully understood. Using a transgenic rat that expresses green fluorescent protein under the promoter of the S100β protein gene, we immunohistochemically detected expression of the luteinizing hormone, thyroid-stimulating hormone, prolactin, growth hormone and proopiomelanocortin by S-100 protein-positive cells located between clusters of hormone-producing cells in the intermediate lobe. These findings lend support to the hypothesis that S-100 protein-positive cells are capable of differentiating into hormone-producing cells in the adult rat pituitary gland.
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页码:425 / 429
页数:4
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