Pharmacological Activity of 4,5-Dihydropyrazole Derivatives (Review)

被引:0
|
作者
D. D. Korablina
N. I. Vorozhtsov
L. A. Sviridova
E. I. Kalenikova
O. S. Medvedev
机构
[1] Moscow State University,
来源
关键词
dihydropyrazole; pyrazoline; anti-inflammatory activity; antitumor activity; antimicrobial activity; pharmacological activity;
D O I
暂无
中图分类号
学科分类号
摘要
The various types of pharmacological activity of 4,5-dihydropyrazole derivatives are reviewed. Attention is focused on the influence of various substituents in the dihydropyrazole core on the pharmacological effects of these compounds.
引用
收藏
页码:281 / 295
页数:14
相关论文
共 50 条
  • [21] Synthesis of polyfluorophenyl substituted-4,5-dihydropyrazole derivatives via 1,3-dipolar cycloaddition of nitrile imine with ethyl acrylate
    Song, LP
    Zhu, SZ
    JOURNAL OF FLUORINE CHEMISTRY, 2003, 124 (02) : 211 - 217
  • [22] Identification of human telomerase inhibitors having the core of N-acyl-4,5-dihydropyrazole with anticancer effects
    Xiao, Xuan
    Ni, Yong
    Jia, Ying-Ming
    Zheng, Min
    Xu, Han-Fei
    Xu, Jun
    Liao, Chenzhong
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 26 (06) : 1508 - 1511
  • [23] SYNTHESIS AND PHARMACOLOGICAL ACTIVITY OF IMIDAZO[4,5-C]PYRIDINE DERIVATIVES
    GLOZMAN, OM
    ORLOVA, EK
    MESHCHERYAKOVA, LM
    VORONINA, TA
    GARIBOVA, TL
    MARKINA, NV
    SMIRNOV, LD
    KHIMIKO-FARMATSEVTICHESKII ZHURNAL, 1989, 23 (08): : 916 - 918
  • [24] A One-Pot Asymmetric Synthesis of a N-Acylated 4,5-Dihydropyrazole, A Key Intermediate of Thrombin Inhibitor AZD8165
    Karlsson, Staffan
    Branalt, Jonas
    Halvarsson, Maria Olwegard
    Bergman, Joakim
    ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2014, 18 (08) : 969 - 975
  • [25] Synthesis, characterization and cytotoxicity of the gold(III) complexes of 4,5-dihydropyrazole-1-carbothioamide derivatives
    Wang, Shuxiang
    Shao, Wenqing
    Li, Hongdong
    Liu, Cui
    Wang, Ke
    Zhang, Jinchao
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2011, 46 (05) : 1914 - 1918
  • [26] Synthesis and structure-activity relationships of miticidal 4,5-dihydropyrazole-5-thiones
    Tada, I
    Motoki, M
    Takahashi, N
    Miyata, T
    Takechi, T
    Uchida, T
    Takagi, Y
    PESTICIDE SCIENCE, 1996, 48 (02): : 165 - 173
  • [27] STRUCTURE OF METHYL (4'S,16S)-3-BETA-ACETOXY-17-OXOSPIROL(5-ANDROSTENE-16,3'-(4,5-DIHYDROPYRAZOLE))-4'-CARBOXYLATE
    GLUZINSKI, P
    KRAJEWSKI, JW
    URBANCZYKLIPKOWSKA, Z
    ARGAY, G
    PARKANYI, L
    ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, 1985, 41 (NOV) : 1630 - 1632
  • [28] Inhibitors of Yellow Fever Virus replication based on 1,3,5-triphenyl-4,5-dihydropyrazole scaffold: Design, synthesis and antiviral evaluation
    Fioravanti, Rossella
    Desideri, Nicoletta
    Carta, Antonio
    Atzori, Elena Maria
    Delogu, Ilenia
    Collu, Gabriella
    Loddo, Roberta
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 141 : 15 - 25
  • [29] Cu(OTf)2-catalyzed three-component annulation reaction: one-pot synthesis of 4,5-dihydropyrazole from aldehydes, hydrazines and alkenes
    Wu, Qiang
    Liu, Pei
    Pan, Ying-ming
    Xu, Yan-li
    Wang, Heng-shan
    RSC ADVANCES, 2012, 2 (27) : 10167 - 10170
  • [30] Synthesis and Fungicidal Activity of 5-Aryl-1-(aryloxyacetyl)-3-(tert-butyl or phenyl)-4-(1H-1,2,4-triazol-1-yl)-4,5-dihydropyrazole
    Mao, Hui-Yu
    Song, Hong
    Shi, De-Qing
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2013, 50 (02) : 216 - 219