Endocrine disruptors and obesity

被引：0
作者：
Jerrold J. Heindel
Retha Newbold
Thaddeus T. Schug
机构：
[1] Population Health Branch,Division of Extramural Research and Training
[2] National Institute of Environmental Sciences,Division of the National Toxicology Program
[3] National Institute of Environmental Health Sciences/National Institutes of Health,undefined
来源：
Nature Reviews Endocrinology | 2015年 / 11卷
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摘要：
Obesity is an increasing global public health problemObesity is a disease of the endocrine system, which involves many tissues and metabolic processesThe rapid growth of the obesity epidemic over the past few decades suggests that environmental factors might have a role in the aetiology of the diseaseObesity probably has its origins during development, when susceptibility to weight gain and alterations in metabolism developObesogens are a subclass of endocrine-disrupting chemicals (EDCs) that might predispose individuals to the development of obesityThe obesogen hypothesis provides a means for the prevention of obesity by reducing exposure to EDCs during early development
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页码：653 / 661
页数：8
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共 296 条
[101]  
Irigaray P(2009)Effects of endocrine disrupting chemicals on Toxicology. 260 126-3005
[102]  
Backes CH(2013) global DNA methylation and adipocyte differentiation J. Biochem. Mol. Toxicol. 27 124-1109
[103]  
Nelin T(2014)Perinatal exposure to low-dose 2,2′,4,4′-tetrabromodiphenyl ether affects growth in rat offspring: what is the role of IGF-1? Toxicol. Lett. 228 93-13
[104]  
Gorr MW(2014)Accumulation and endocrine disrupting effects of the flame retardant mixture Firemaster Environ. Health Perspect. 122 1225-634
[105]  
Wold LE(2013) 550 in rats: an exploratory assessment Toxicol. Lett. 216 40-494
[106]  
Vadillo-Ortega F(2010) assessment of human nuclear hormone receptor activity and cytotoxicity of the flame retardant mixture FM 550 and its triarylphosphate and brominated components Int. J. Environ. Res. Public Health 7 2988-733
[107]  
Rundle A(2013)Ligand binding and activation of PPARγ by Firemaster Environ. Health Perspect. 121 1103-629
[108]  
Jerrett M(2014) 550: effects on adipogenesis and osteogenesis Am. J. Clin. Nutr. 99 5-1129
[109]  
Bolton JL(2007)The dynamics of accumulation of PCBs in cultured adipocytes vary with the cell lipid content and the lipophilicity of the congener Int. J. Hyg. Environ. Health 210 623-56
[110]  
Zheng Z(2015)Endocrine disruptors and obesity: an examination of selected persistent organic pollutants in the NHANES 1999–2002 data Front. Endocrinol. 6 8-19166
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