Solid-Supported Parallel Synthesis of Hydroxybenzylamine Libraries Possessing Antileishmial Activity

被引：0
|
作者：
Guillermo R. Labadie
Paolo B. Carvalho
Sanjay Batra
Seoung-Ryoung Choi
Sabana I. Khan
Babu L. Tekwani
Mitchell A. Avery
机构：
[1] University of Mississippi,Department of Medicinal Chemistry, School of Pharmacy
[2] University of Mississippi,Department of Chemistry
[3] University of Mississippi,National Center for Natural Products Research
[4] Universidad Nacional de Rosario,Departamento de Química Orgánica, Facultad de Ciencias Bioquímicas y Farmacéuticas
来源：
Medicinal Chemistry Research | 2005年 / 14卷
关键词：
Plasmodium; Plasmodium Falciparum; Reductive Amination; Antileishmial Activity; Parallel Synthesis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A concise solid-supported parallel synthesis of 64 compounds is described. Starting with isovanillin, a two-step sequence involving reductive amination and N-benzylation was performed to provide the compounds in good purity. The library has been tested against Leishmania donovani and Plasmodium falciparum, with activity at the micromolar level.
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页码：332 / 346
页数：14
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