Effect of Di-(2-ethylhexyl)-phthalate on Sphingolipid Metabolic Enzymes in Rat Liver

被引：0
|
作者：
Ji-Yeong Jo
Tae-Hyung Kim
Hye-Young Jeong
Sung-Mee Lim
Hyung-Sik Kim
Dong-Soon Im
机构：
[1] Pusan National University,Laboratory of Pharmacology, College of Pharmacy
[2] Pusan National University,Molecular Toxicology, College of Pharmacy (BK21 Project) and Longevity Life Science and Technology Institutes
[3] Tongmyong University,Department of Food Science & Technology
来源：
Toxicological Research | 2011年 / 27卷 / 3期
关键词：
Di-(2-ethylhexyl)-phthalate; Sphingosine; Sphingomyelinase; Ceramidase; Liver; Sphingomyelin synthase; Ceramide synthase;
D O I：
10.5487/TR.2011.27.3.185
中图分类号：
学科分类号：
摘要：
Di-(2-ethylhexyl)-phthalate (DEHP), the most widely utilized industrial plastizer and a ubiquitous environmental contaminant, can act on peroxisome proliferators-activated nuclear hormone receptor family (PPAR) isoforms. To understand the contribution of sphingolipid metabolism to DEHP-induced hepatotox-icity, effect of DEHP exposure on activities of sphingolipid metabolic enzymes in rat liver was investigated. DEHP (250, 500 or 750 mg/kg) was administered to the rats through oral gavage daily for 28 days. The activities of acidic and alkaline ceramidases were slightly increased in 250 mg/kg DEHP-adminis-tered rat livers and significantly elevated in 500 mg/kg DEHP-administered ones, although the level of 750 mg/kg DEHP-administered ones was not increased. Neutral ceramidase, acidic and neutral sphingomyeli-nases, sphingomyeline synthase and ceramide syhthase were not changed at all by DEHP exposure. Therefore, acidic and alkaline ceramidases might play important roles in DEHP-induced hepatotoxicity.
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页码：185 / 190
页数：5
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