Emerging roles of low-density lipoprotein in the development and treatment of breast cancer

被引：0

作者：

Xuefeng Guan

Zhuo Liu

Zhen Zhao

Xuefeng Zhang

Siteng Tao

Bao Yuan

Jiabao Zhang

Dawei Wang

Qing Liu

Yu Ding

机构：

[1] JiLin University in Changchun of Jilin Province in China,Department of Laboratory Animals, College of Animal Sciences

[2] Guangdong Provincial Hospital of Chinese Medicine-Zhuhai Hospital,College of Animal Science and Technology

[3] China-Japan Union Hospital of Jilin University,Department of Immunology, School of Basic Medical Sciences

[4] Jilin Agricultural University,The 2nd Clinical School of Medicine

[5] Fudan University,undefined

[6] Guangdong Provincial Hospital of Chinese Medicine,undefined

[7] Guangzhou University of Chinese Medicine,undefined

[8] The 85th Hospital of CPLA,undefined

来源：

Lipids in Health and Disease | / 18卷

关键词：

Breast cancer; LDL; Heterogeneous; Progression; Prognosis; Treatment;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Breast cancer is a heterogeneous disease with increasing incidence and mortality and represents one of the most common cancer types worldwide. Low-density lipoprotein (LDL) is a complex particle composed of several proteins and lipids, which carries cholesterol into peripheral tissues and also affects the metabolism of fatty acids. Recent reports have indicated an emerging role of LDL in breast cancer, affecting cell proliferation and migration, thereby facilitating disease progression. However, controversy still exists among distinct types of breast cancer that can be affected by LDL. Classical therapeutic approaches, such as radiotherapy, chemotherapy, and lipid-lowering drugs were also reported as affecting LDL metabolism and content in breast cancer patients. Therefore, in this review we summarized and discussed the role of LDL in the development and treatment of breast cancer.

引用

共 228 条

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