Associations between bullous pemphigoid and primary malignant cancers: an English national record linkage study, 1999–2011

被引:0
作者
Eugene Ong
Raph Goldacre
Uy Hoang
Rodney Sinclair
Michael Goldacre
机构
[1] University of Oxford,Unit of Health
[2] University of Melbourne,Care Epidemiology, Nuffield Department of Population Health
来源
Archives of Dermatological Research | 2014年 / 306卷
关键词
Bullous pemphigoid; Malignant cancer; Risk; Association; Cohort; Kidney cancer;
D O I
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学科分类号
摘要
We conducted a nationwide record-linked study using all English NHS hospital admission data and mortality statistics from 1999 to 2011 to evaluate the risk of concurrent or subsequent bullous pemphigoid (BP) in a cohort of 2,873,720 individuals with malignant cancers, when compared with a reference cohort. We calculated standardised rate ratios (RRs) based on person-years at risk, comparing the observed and expected numbers of BP cases in the cancer cohort with those in the reference cohort. Overall, the cohort of people with a record of a malignant cancer was not found to be at greater risk of concurrent or subsequent BP than the cohort of people without a record of a malignant cancer (RR 0.96, 95 % CI 0.88–1.04), although elevated risks of BP were found in sub-cohorts of people with either kidney cancer, laryngeal cancer or lymphoid leukaemia. We also similarly analysed the risk of concurrent and subsequent malignant cancers in a cohort of people with a principal diagnosis of BP, and again found no increased risk as compared with the reference cohort (RR 1.00, 95 % CI 0.92–1.09).
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页码:75 / 80
页数:5
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