Time-related improvement of survival in resectable gastric cancer: The role of Japanese-style gastrectomy with D2 lymphadenectomy and adjuvant chemotheraphy

被引：7

作者：

Grau J.J. ^{[1
]}

Palmero R. ^{[1
]}

Marmol M. ^{[1
]}

Domingo-Domenech J. ^{[1
]}

Monzo M. ^{[1
]}

Fuster J. ^{[2
]}

Vidal O. ^{[2
]}

Fondevila C. ^{[2
]}

Garcia-Valdecasas J.C. ^{[2
]}

机构：

[1] Oncology Department, ICMHO (Institut Clinic de Malalties Hemato-Oncologiques), University of Barcelona, Barcelona

[2] Gastrointestinal Surgery Depart., University of Barcelona, Hospital Clinic, Barcelona

来源：

World Journal of Surgical Oncology | / 4卷 / 1期

关键词：

Gastric Cancer; Adjuvant Chemotherapy; Gastric Cancer Patient; Total Gastrectomy; Tegafur;

D O I：

10.1186/1477-7819-4-53

中图分类号：

学科分类号：

摘要：

Background: We investigated the change of prognosis in resected gastric cancer (RGC) patients and the role of radical surgery and adjuvant chemotherapy. Methods: We retrospectively analyze the outcome of 426 consecutive patients from 1975 to 2002, divided into 2 time-periods (TP) cohort: Before 1990 (TP1, n = 207) and 1990 or after (TP2; n = 219). Partial gastrectomy and D1-lymphadenetomy was predominant in TP1 and total gastrectomy with D2-lymphadenectomy it was in TP2. Adjuvant chemotherapy consisted of mitomycin C (MMC), 10-20 mg/m2 iv 4 courses or MMC plus Tegafur 500 mg/m2 for 6 months. Results: Positive nodes were similar in TP2/TP1 patients with 56%/59% respectively. Total gastrectomy was done in 56%/45% of TP2/TP1 respectively. Two-drug adjuvant chemotherapy was administered in 65%/18% of TP2/TP1 respectively. Survival at 5 years was 66% for TP2 versus 42% for TP1 patients (p < 0.0001). Survival by stages II, IIIA y IIIB for TP2 versus TP1 patients was 70 vs. 51% (p = 0.0132); 57 vs. 22% (p = 0.0008) y 30 vs. 15% (p = 0.2315) respectively. Multivariate analysis showed that age, stage of disease and period of treatment were independent variables. Conclusion: The global prognosis and that of some stages have improved in recent years with case RGC patients treated with surgery and adjuvant chemotherapy. © 2006 Grau et al; licensee BioMed Central Ltd.

引用

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