Metabolomic prediction of treatment outcome in pancreatic ductal adenocarcinoma patients receiving gemcitabine

被引:0
作者
Lee Cheng Phua
Shixu Goh
David Wai Meng Tai
Wei Qiang Leow
Syed Muhammad Fahmy Alkaff
Chung Yip Chan
Juinn Huar Kam
Tony Kiat Hon Lim
Eric Chun Yong Chan
机构
[1] Singapore General Hospital,Department of Clinical Translational Research
[2] National University of Singapore,Department of Pharmacy, Faculty of Science
[3] National Cancer Centre Singapore,Division of Medical Oncology
[4] Singapore General Hospital,Department of Pathology
[5] Singapore General Hospital,Department of Hepato
来源
Cancer Chemotherapy and Pharmacology | 2018年 / 81卷
关键词
Metabonomics; Metabolomics; Metabolic profiling; Gas chromatography/time-of-flight mass spectrometry; Pancreatic ductal adenocarcinoma; Pharmacometabonomics; Pharmacometabolomics; Gemcitabine;
D O I
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中图分类号
学科分类号
摘要
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收藏
页码:277 / 289
页数:12
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[1]  
3rd Burris HA(1997)Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial J Clin Oncol 15 2403-2413
[2]  
Moore MJ(2011)Molecular predictors of gemcitabine response in pancreatic cancer World J Gastrointest Oncol 3 153-164
[3]  
Andersen J(2009)Human equilibrative nucleoside transporter 1 levels predict response to gemcitabine in patients with pancreatic cancer Gastroenterology 136 187-195
[4]  
Green MR(2014)Pancreatic cancer hENT1 expression and survival from gemcitabine in patients from the ESPAC-3 trial J Natl Cancer Inst 106 djt347-674
[5]  
Rothenberg ML(2012)Levels of gemcitabine transport and metabolism proteins predict survival times of patients treated with gemcitabine for pancreatic adenocarcinoma Gastroenterology 143 664-312
[6]  
Modiano MR(2014)Human equilibrative nucleoside transporter 1 predicts survival in patients with pancreatic cancer treated with gemcitabine: a meta-analysis Genet Test Mol Biomark 18 306-2497
[7]  
Cripps MC(2006)Immunohistochemical and genetic evaluation of deoxycytidine kinase in pancreatic cancer: relationship to molecular mechanisms of gemcitabine resistance and survival Clin Cancer Res 12 2492-4572
[8]  
Portenoy RK(2009)The role of HuR in gemcitabine efficacy in pancreatic cancer: HuR Up-regulates the expression of the gemcitabine metabolizing enzyme deoxycytidine kinase Cancer Res 69 4567-394
[9]  
Storniolo AM(2007)Ribonucleotide reductase subunit M2 mRNA expression in pretreatment biopsies obtained from unresectable pancreatic carcinomas J Gastroenterol 42 389-8490
[10]  
Tarassoff P(2014)hENT1 expression is predictive of gemcitabine outcome in pancreatic cancer: a systematic review World J Gastroenterol 20 8482-111