Metabolic Syndrome in Children and Adolescents: Looking to New Markers

被引：0
作者：
Fazeli M. [1 ]
Mohammad-Zadeh M. [2 ]
Meshkat Z. [3 ]
Ghazizadeh H. [4 ,5 ,6 ]
Barati E. [5 ]
Ferns G.A. [7 ]
Ghayour-Mobarhan M. [5 ,6 ]
机构：
[1] Department of Genetic and Molecular Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad
[2] Cellular and Molecular Research Center, Sabzevar University of Medical Sciences, Sabzevar
[3] Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad
[4] Student Research Committee, Mashhad University of Medical Sciences, Mashhad
[5] Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad
[6] International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad
[7] Division of Medical Education, Brighton & Sussex Medical School, Falmer, Brighton, Sussex
来源：
Current Treatment Options in Pediatrics | 2021年 / 7卷 / 3期
关键词：
Adolescents; Biomarker; Metabolic syndrome; Pediatrics;
D O I：
10.1007/s40746-021-00226-7
中图分类号：
学科分类号：
摘要：
Metabolic syndrome (MetS) was first defined by Reaven, but its diagnostic criteria are controversial, particularly in children and adolescents. MetS is a common health problem globally, and many studies revealed its association with diabetes and cardiovascular diseases, and hence an agreed definition would be useful. To date, many attempts have been performed to achieve consensus and a more accurate definition by investigating new criteria, and introducing new markers and cutoff values. The prevalence of MetS varies greatly, in part due to the application of these different criteria. This variation in definition makes it difficult for public health professionals to accurately identify and manage MetS in pediatrics. New components in defining MetS, such as hyperuricemia, have been added to the standard criteria. An attempt has also been made to identify reliable biomarkers for the identification of MetS, but these have been inconsistent. Even for standard components including obesity, new cutoff criteria that have been adopted for different ethnicities, and gender, the search for a better understanding of MetS is continuing especially in pediatrics. © 2021, The Author(s), under exclusive licence to Springer Nature Switzerland AG.
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页码：152 / 166
页数：14
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