Prognostic importance of the platelet count 100 days post allogeneic bone marrow transplant

被引:0
|
作者
B Bolwell
B Pohlman
R Sobecks
S Andresen
S Brown
L Rybicki
V Wentling
M Kalaycio
机构
[1] Taussig Cancer Center,Department of Hematology and Medical Oncology
[2] The Cleveland Clinic Foundation,Department of Biostatistics and Epidemiology
[3] Taussig Cancer Center,undefined
[4] The Cleveland Clinic Foundation,undefined
来源
关键词
allogeneic BMT; prognostic factors; post transplant platelet count;
D O I
暂无
中图分类号
学科分类号
摘要
We assessed the prognostic importance of the platelet count 100 days post transplant of 107 consecutive patients receiving ablative allogeneic bone marrow transplant (BMT) between 7/96 and 12/00 who survived at least 100 days. Diagnoses included AML (n=36), chronic myelogenous leukemia (n=27), NHL (n=14), ALL (n=16), MDS (n=9), aplastic anemia (n=3), and one Hodgkin's disease and myelofibrosis each. In total, 64% were in remission or in chronic phase or had aplastic anemia (good risk), and 36% had active disease at the time of transplant (bad risk). In all, 70% were matched sibling transplants and 30% were matched unrelated donor transplants. The mean follow-up for the patients remaining alive is 48 months. Survival was powerfully influenced by the 100-day platelet count: 4-year survival was 19% for patients with a platelet count <30 × 109/l; 41% for patients with a platelet count of 30–50; and 72% for those with a platelet count >50 (P<0.001; log-rank test). In a multivariable analysis, the most powerful risk factors for mortality after allogeneic BMT were low 100-day platelet count (P<0.001) and bad risk disease (P=0.009). We conclude that the platelet count 100 days post transplant is a powerful predictor of overall survival.
引用
收藏
页码:419 / 423
页数:4
相关论文
共 50 条
  • [41] Constrictive pericarditis post allogeneic bone marrow transplant for Philadelphia-positive acute lymphoblastic leukaemia
    Cavet, J
    Lennard, A
    Gascoigne, A
    Finney, RD
    Lucraft, HH
    Richardson, C
    Taylor, PRA
    Proctor, SJ
    Jackson, GH
    BONE MARROW TRANSPLANTATION, 2000, 25 (05) : 571 - 573
  • [42] Impact of cytogenetics on disease relapse post-allogeneic bone marrow transplant for acute myeloid leukaemia
    Michelis, F. V.
    Atenafu, E. G.
    Gupta, V.
    Kim, D.
    Kuruvilla, J.
    Lambie, A.
    Lipton, J. H.
    Loach, D.
    Uhm, J.
    Messner, H. A.
    BONE MARROW TRANSPLANTATION, 2013, 48 : S390 - S391
  • [43] Infections among allogeneic bone marrow transplant recipients in India
    George, B
    Mathews, V
    Srivastava, A
    Chandy, M
    BONE MARROW TRANSPLANTATION, 2004, 33 (03) : 311 - 315
  • [44] Infections among allogeneic bone marrow transplant recipients in India
    B George
    V Mathews
    A Srivastava
    M Chandy
    Bone Marrow Transplantation, 2004, 33 : 311 - 315
  • [45] Hypophosphatemia and hypouricemia in pediatric allogeneic bone marrow transplant recipients
    Uçkan, D
    Çetin, M
    Dida, A
    Batu, A
    Tuncer, M
    Tezcan, I
    PEDIATRIC TRANSPLANTATION, 2003, 7 (02) : 98 - 101
  • [46] Transjugular liver biopsy in allogeneic bone marrow transplant.
    Arai, S
    Lee, L
    Boitnott, J
    Lund, G
    Johnson, C
    Margolis, J
    Vogelsang, G
    BLOOD, 1999, 94 (10) : 148A - 148A
  • [47] ALLOGENEIC BONE-MARROW TRANSPLANT IN CHRONIC MYELOGENOUS LEUKEMIA
    SPECK, B
    GRATWOHL, A
    NISSEN, C
    OSTERWALDER, B
    MULLER, M
    BANNERT, P
    MULLER, HJ
    JEANNET, M
    SCHWEIZERISCHE MEDIZINISCHE WOCHENSCHRIFT, 1982, 112 (41) : 1419 - 1420
  • [48] DISCHARGE TEACHING FOR AUTOLOGOUS AND ALLOGENEIC BONE MARROW TRANSPLANT PATIENTS
    Lalani, Tanya
    Fincher, Brandi
    Doubleday, Erica
    ONCOLOGY NURSING FORUM, 2021, 48 (02) : 91 - 91
  • [49] Life After Allogeneic Bone Marrow Transplant: The New Normal
    Warbet, R.
    Cammarata, M.
    PSYCHO-ONCOLOGY, 2012, 21 : 24 - 24
  • [50] Disseminated histoplasmosis in allogeneic bone marrow transplant: a diagnosis not to be missed
    Haydoura, S.
    Wallentine, J.
    Lopansri, B.
    Ford, C. D.
    Saad, D.
    Burke, J. P.
    TRANSPLANT INFECTIOUS DISEASE, 2014, 16 (05) : 822 - 826