Glucose rapidly decreases plasma membrane GLUT4 content in rat skeletal muscle

被引：0
|
作者：
André Marette
Dimitrios Dimitrakoudis
Qing Shi
Carol D. Rodgers
Amira Klip
Mladen Vranic
机构：
[1] Laval University Hospital Research Centre (CHUL),Department of Physiology and Lipid Research Unit
[2] University of Toronto,Department of Physiology, Faculty of Medicine
[3] University of Toronto,Department of Medicine, Faculty of Medicine
[4] The Hospital for Sick Children,Department of Programme in Cell Biology
来源：
Endocrine | 1999年 / 10卷
关键词：
Glucose transporter; GLUT1; phlorizin; glycemia; streptozotocin;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We have previously demonstrated that chronic hyperglycemia per se decreases GLUT4 glucose transporter expression and plasma membrane content in mildly streptozotocin- (STZ) diabetic rats (Biochem. J. 284, 341–348, 1992). In the present study, we investigated the effect of an acute rise in glycemia on muscle GLUT4 and GLUT1 protein contents in the plasma membrane, in the absence of insulin elevation. Four experimental groups of rats were analyzed in the postabsorptive state:Control rats.Hyperglycemic STZ-diabetic rats with moderately reduced fasting insulin levels.STZ-diabetic rats made normoglycemic with phlorizin treatment.Phlorizin-treated (normoglycemic) STZ-diabetic rats infused with glucose for 40 min.
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页码：13 / 18
页数：5
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