Effect of short term supplementation of tomatoes on antioxidant enzymes and lipid peroxidation in type -II diabetes

被引：23

作者：

Bose K.S.C. ^{[1
,2
]}

Agrawal B.K. ^{[1
]}

机构：

[1] Department of Biochemistry, People's College of Medical Sciences and Research Centre, Bhanpur, Bhopal (M.P.), Bypass Road

[2] Department of Biochemistry, People's College of Medical Sciences and Research Centre, Bhanpur, Bhopal- 462010(M.P.), Bypass road

来源：

Indian Journal of Clinical Biochemistry | 2007年 / 22卷 / 1期

关键词：

Catalase; Glutathione peroxidase; Glutathione reductase; Malondialdehyde; Reduced glutathione; Super oxide dismutase; Tomoto lycopene;

D O I：

10.1007/BF02912889

中图分类号：

学科分类号：

摘要：

The objective of the present study is to evaluate the beneficial effect of tomatoes, which are rich source of Lycopene, relatively a new carotenoid known to play an important role in human health and disease. In this study lipid peroxidation rate was measured by estimating Malondialdehyde and the levels of serum enzymes involved in antioxidant activities like Super Oxide Dismutase, Glutathione Peroxidase, Glutathione Reductase, Reduced Glutathione, in type-II diabetic group (n = 40) and age matched control group (n = 50), and observed significantly lower levels of antioxidant enzymes and very high lipid peroxidation rate in type-II diabetes when compared to control group (p<0.001). Short term supplementation with tomatoes (cooked) to diabetic group for a period of 30 days, showed a significant improvement in antioxidant enzyme levels (p<0.001) and decreased lipid peroxidation rate (p<0.001) suggesting the supplementation with tomato lycopene may serve as the best method of preventing the oxidative stress in diabetic patients.

引用

页码：95 / 98

页数：3

共 18 条

[1]

Zimmet P.Z., Mccarty D.J., De Couten M.P., The global Epidemiology of non insulin dependent diabetes mellitus and the metabolic syndrome, Journal of diabetes and its complications, 11, pp. 60-68, (1997)

[2]

Zimmet P.Z., Lefebvre P., The global NIDDM epidemic, Diabetology, 39, pp. 1247-1248, (1996)

[3]

Pfaffly J.R., Review on Diabetic complications, Free radicals in biology and medicine, 77, (2001)

[4]

Baynes J.W., Role of oxidative stress in development of complications in diabetes, Diabetes, 40, pp. 405-411, (1991)

[5]

Agrawal S., Rao A.V., Tomato lycopene and low density lipoprotein oxidation a human dietary intervention study, Lipids, 33, pp. 981-984, (1998)

[6]

Agrawal S., Rao A.V., Role of lycopene as antioxidant carotenoids in the prevention of chronic diseases, a review, Nutrition Research, 19, pp. 305-323, (1999)

[7]

Khachik F., Carvalho L., Bernstein P.S., Muir F.J., Chemistry, distribution and metabolism of tomato carotenoids and their impact on human health, Experimental Biology and Medicine, 227, pp. 845-851, (2002)

[8]

Jane E., Upritchard, Wayne H., F, Sutherland Jim I Mann. Effect of supplementation with tomato juice, vitamin E and C on LDL oxidation and products of inflammatory activity in type-II diabetes, Diabetes Care, 23, pp. 733-738, (2000)

[9]

Ford E.S., Will J.C., Bowman B.A., Narayan K.M., Diabetes Mellitus and serum carotenoids findings from the third national and nutritional examination survey, American Journal of Epidemiology, 149, pp. 168-176, (1999)

[10]

Coyne T., Ibiebele T.I., Baade P.D., Dobson A., McClintock C., Dunn S., Et al., Diabetes mellitus and serum carotenoids

← 1 2 →