Modification of biologically active amides and amines with fluorine-containing heterocycles 7. Fluorine-containing heterocyclic derivatives of the acetazolamide

被引：0
作者：
V. B. Sokolov
A. Yu. Aksinenko
机构：
[1] Russian Academy of Sciences,Institute of Physiologically Active Substances
来源：
Russian Chemical Bulletin | 2012年 / 61卷
关键词：
acetazolamide; methyl trifluoropyruvate; 6-aminouracils; 6-aminothiouracils; -substituted ureas; fluorine-containing hexahydro-1; -pyrrolo[2,3-; ]pyrimidines; 2,5-dioxo-imidazolidines; cyclocondensation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
An approach is proposed to modification of a medical product acetazolamide (N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide) by interaction of 2-(5-acetylamino-1,3,4-thiadiazole-2-yl)sulfonyl imine methyl trifluoropyruvate, which is in-situ generated from acetazolamide, with 1,3-binucleophiles: 6-aminouracils, 6-aminothiouracils, and N-substituted ureas, to yield heterocyclic compounds with the CF3 substituent in the nitrogen-containing mono- or bicycle.
引用
收藏
页码：2124 / 2128
页数：4
相关论文
共 42 条
[1]  
Sokolov V B(2012)undefined Russ. Chem. Bull. (Int. Ed.) 61 1965-undefined
[2]  
Aksinenko A Yu(2003)undefined Neurology 61 1157-undefined
[3]  
Sibon I(1978)undefined J. Lab. Clin. Med. 92 262-undefined
[4]  
Ghorayer I(2005)undefined Russ. Chem. Bull. (Int. Ed.) 54 472-undefined
[5]  
Henry P(2005)undefined Russ. Chem. Bull. (Int. Ed.) 54 1667-undefined
[6]  
Zwillich C W(2006)undefined Russ. Chem. Bull. (Int. Ed.) 55 1052-undefined
[7]  
Natalino M R(2007)undefined Russ. Chem. Bull. (Int. Ed.) 56 2247-undefined
[8]  
Sutton F D(2007)undefined Russ. Chem. Bull. (Int. Ed.) 56 2252-undefined
[9]  
Weil J V(2010)undefined Russ. Chem. Bull. (Int. Ed.) 59 197-undefined
[10]  
Sokolov V B(2010)undefined Russ. Chem. Bull. (Int. Ed.) 59 288-undefined
12345