Synthesis, characterization, and antitumor activity of new copper(I) and mercury(II) complexes

被引:0
作者
S. A. Aly
机构
[1] Sadat City University,Department of Environmental Biotechnology, Genetic Engineering and Biotechnology Research Institute
来源
Russian Journal of General Chemistry | 2017年 / 87卷
关键词
Anticancer activity; Cu(I) complexes; Hg(II) complexes; IR; UV; TGA;
D O I
暂无
中图分类号
学科分类号
摘要
A series of new copper(I) and mercury(II) complexes with 4-aminoantipyrine, semicarbazide, and thiosemicarbazide ligands [(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)carbonohydrazonoyl dicyanide (HL1), 2-cyano-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-[(E)-(3-methylphenyl)-diazenyl]acetamide (H2L2), (Z)-2-cyano-N′-[(E)-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-methylidene]-2-(2-phenylhydrazinylidene)acetohydrazide (HL3), 2-(anilinoacetyl)-N-phenylhydrazine-1-carbothioamide (H2L4), 2-(anilinoacetyl)-N-(3-methylphenyl)hydrazine-1-carbothioamide (H2L5), and 2-anilino-N′-[(E)-(2-hydroxyphenyl)methylidene]acetohydrazide (H2L6)] have been prepared and characterized by physical and spectral data, including microanalysis, IR and UV-visible spectra, conductivity measurements, and thermal analyses (DTG/TGA). The ligands H2L2 and HL3 produced dinuclear complexes. Thermal studies revealed that the copper(I) complexes are thermally more stable than mercury(II) complexes. The copper complexes exhibited potent inhibitory effect on the MCF7 human breast carcinoma cell line, as compared to mercury(II) complexes.
引用
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页码:1256 / 1263
页数:7
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