Synthesis and biological activity of new pyranochromen-3-carboxamides

被引：0

作者：

R. V. Shutov

E. V. Kuklina

N. A. Anisimova

E. P. Anan’ev

N. I. Kotova

V. N. Kuklin

机构：

[1] St. Petersburg State Chemico-Pharmaceutical Academy,

来源：

Pharmaceutical Chemistry Journal | 2012年 / 46卷

关键词：

pyranochromen-3-carboxamides; 3-formylchromones; synthesis; structure; analgesic; anxiolytic; and antimicrobial activity;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

A series of new pyranochromen-3-carboxamides have been synthesized in good yield by reacting 2-phenyl-4-hydroxy-6H-1,3-thiazin-6-ones with substituted 3-formylchromones. Pharmacological screening showed an influence of the substituent in the 9-position of the pyranochromen-3-carboxamides on the acute toxicity and antifungal, analgesic, and anxiolytic activity. 9-Bromo-2H,5H-pyranochromen-3-carboxamide can be recommended for further pharmacological investigation.

引用

页码：10 / 14

页数：4