Serum lactate dehydrogenase alone is not a helpful prognostic factor in resected colorectal cancer patients

被引：7
作者：
Caputo D. [1 ]
Caricato M. [1 ]
Vincenzi B. [2 ]
La Vaccara V. [1 ]
Mascianà G. [1 ]
Coppola R. [1 ]
机构：
[1] Department of General Surgery, University Campus Bio-Medico di Roma, 00128 Rome, Via Alvaro del Portillo
[2] Department of Medical Oncology, University Campus Bio-Medico di Roma, 00128 Rome, Via Alvaro del Portillo
来源：
Updates in Surgery | 2014年 / 66卷 / 3期
关键词：
Colorectal cancer; LDH;
D O I：
10.1007/s13304-014-0260-5
中图分类号：
学科分类号：
摘要：
Several studies showed how serum levels of lactate dehydrogenase (LDH) are related with a worse prognosis and response to therapy. Its role in colorectal cancer is not still assessed. The aim of this study was to assess the prognostic role of serum level of LDH in non-metastatic, previously untreated, T2-T3-T4 colorectal tumours undergoing surgery. Data regarding preoperative serum levels of LDH have been retrospectively collected. A group with normal levels of serum LDH (group A) and a group with high levels of serum LDH (group B) have been identified and compared in relation with disease staging and outcome. A series of 96 cases have been analysed. Only age was significantly associated with increased LDH serum level (p 0.001). No significant differences between serum LDH levels, staging pT (p 0.721), pN (p 0.080) and grading (0.849) have been found. Test's sensitivity and specificity were 76 and 46.5 %, respectively. Preoperative serum levels of LDH alone failed to demonstrate a prognostic role in a selected series of colorectal cancer patients. Low rates of sensitivity and specificity have been found. © 2014 Springer-Verlag Italia.
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页码：211 / 215
页数：4
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