Comparison of the thermodynamic properties of structurally related amphiphilic antidepressants in aqueous solution

被引：0
作者：
P. Taboada
J. M. Ruso
M. García
V. Mosquera
机构：
[1] Grupo de Física de Coloides y Polímeros Departamento de Física de la Materia Condensada y Departamento de Física Aplicada,
[2] Facultad de Física Universidad de Santiago de Compostela 15706 Santiago de Compostela Spain e-mail: fmvictor@usc.es Tel.: +34-981-563100 Fax: +34-981-520676,undefined
来源：
Colloid and Polymer Science | 2001年 / 279卷
关键词：
Key words Amitriptyline; Desipramine; Nortriptyline; Critical micelle concentration; Thermodynamic parameters;
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学科分类号：
摘要：
 The critical concentrations of amitriptyline, desipramine and nortriptyline hydrochlorides in aqueous solution were determined over the temperature range 288–313 K by a method based on deconvolution into Gaussians of the second derivate of the measured specific conductivity data. The mass-action model was used to calculate the thermodynamic quantities: standard free Gibbs energy, standard enthalpy and standard entropy of aggregate formation. The results are discussed in terms of the structure of the drug aggregates.
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页码：716 / 720
页数：4
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