Human tumor-derived vs dendritic cell-derived exosomes have distinct biologic roles and molecular profiles

被引：0
作者：
Eva Wieckowski
Theresa L. Whiteside
机构：
[1] University of Pittsburgh School of Medicine,Department of Pathology, Immunology and Otolaryngology
[2] University of Pittsburgh Cancer Institute,Hillman Cancer Center
来源：
Immunologic Research | 2006年 / 36卷
关键词：
Exosomes; Microvesicles; Human tumors; Dendritic cells; T cells; Apoptosis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Microvesicles (MV) or exosomes are produced and secreted by tumor and normal cells. The molecular profile and functions of tumor-derived vs dendritic cell (DC)-derived MV are distinct. The former express death ligands and mediate apoptosis of activated T cells. The latter promote CD4+T cell proliferation and may play a role in regulating T cell responses. Serving as intercellular communication networks, tumor-derived MV contribute to tumor escape, while DC-derived MV drive and regulate immune response.
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页码：247 / 254
页数：7
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