DNA Repair Mechanisms and Therapeutic Targets in Glioma

[1] Louis DN(2016)The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary Acta Neuropathol. 131 803-820

[2] Perry A(2001)Genome maintenance mechanisms for preventing cancer Nature. 411 366-374

[3] Reifenberger G(2001)ATM protein expression correlates with radioresistance in primary glioblastoma cells in culture International Journal of Radiation Oncology*Biology*Physics 50 511-523

[4] von Deimling A(2004)Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM Cancer Res. 64 9152-9159

[5] Figarella-Branger D(2018)The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models Sci Adv 4 eaat1719-3200

[6] Cavenee WK(2013)ATM kinase inhibition preferentially sensitizes p53-mutant glioma to ionizing radiation Clin Cancer Res. 19 3189-4428

[7] Ohgaki H(2012)Targeting ATR in vivo using the novel inhibitor VE-822 results in selective sensitization of pancreatic tumors to radiation Cell Death Dis. 3 76-4338

[8] Wiestler OD(2018)ATR kinase inhibitors NVP-BEZ235 and AZD6738 effectively penetrate the brain after systemic administration Radiat Oncol 13 2910-1101

[9] Kleihues P(2019)Myc targeted CDK18 promotes ATR and homologous recombination to mediate PARP inhibitor resistance in glioblastoma Nature Communications. 10 4416-1216

[10] Ellison DW(2015)Selective inhibition of parallel DNA damage response pathways optimizes radiosensitization of glioblastoma stem-like cells Cancer Research. 75 4331-10476

[1] Louis DN(2016)The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary Acta Neuropathol. 131 803-820

[2] Perry A(2001)Genome maintenance mechanisms for preventing cancer Nature. 411 366-374

[3] Reifenberger G(2001)ATM protein expression correlates with radioresistance in primary glioblastoma cells in culture International Journal of Radiation Oncology*Biology*Physics 50 511-523

[4] von Deimling A(2004)Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM Cancer Res. 64 9152-9159

[5] Figarella-Branger D(2018)The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models Sci Adv 4 eaat1719-3200

[6] Cavenee WK(2013)ATM kinase inhibition preferentially sensitizes p53-mutant glioma to ionizing radiation Clin Cancer Res. 19 3189-4428

[7] Ohgaki H(2012)Targeting ATR in vivo using the novel inhibitor VE-822 results in selective sensitization of pancreatic tumors to radiation Cell Death Dis. 3 76-4338

[8] Wiestler OD(2018)ATR kinase inhibitors NVP-BEZ235 and AZD6738 effectively penetrate the brain after systemic administration Radiat Oncol 13 2910-1101

[9] Kleihues P(2019)Myc targeted CDK18 promotes ATR and homologous recombination to mediate PARP inhibitor resistance in glioblastoma Nature Communications. 10 4416-1216

[10] Ellison DW(2015)Selective inhibition of parallel DNA damage response pathways optimizes radiosensitization of glioblastoma stem-like cells Cancer Research. 75 4331-10476