The effects of dopamine D1/D2 receptor agonists and blockers on the behavior of rats with different choices of reinforcement value

被引：0

作者：

Zaichenko M.I. ^{[1
]}

Merzhanova G.Kh. ^{[1
]}

机构：

[1] Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, 117485 Moscow

来源：

Neuroscience and Behavioral Physiology | 2014年 / 44卷 / 6期

关键词：

dopamine receptors; impulsivity; raclopride; reinforcement; SCH; 23390; self-control;

D O I：

10.1007/s11055-014-9968-4

中图分类号：

学科分类号：

摘要：

The effects of the dopamine D1 and D2 receptor agonists SKF and TNPA and the antagonists SCH 23390 and raclopride on the behavior of rats making different choices of reinforcement value were studied. Animals were separated into two typological groups - a group of impulsive animals, selecting low-value immediate reinforcement, and a group of self-controlled animals, preferring a valuable but delayed reinforcement (the delay-discount paradigm). Our results showed that systemic administration of D1 and D2 receptor antagonists SCH 23390 and raclopride led to increases in choosing the pedal delivering the immediate low-value reinforcement only in self-controlled animals. All animals showed increases in the numbers of missed reactions. Administration of the D1 and D 2 receptor agonists SKF and TNPA produced differently directed and insignificant changes in reinforcement delivery pedal selection - self-controlled rats showed a decrease in the number of presses on the pedal delivering the valuable delayed reinforcement, while impulsive animals, conversely, showed an increase in the number of presses on the pedal delivering the more valuable reinforcement. Thus, these results provide evidence that changes in dopamine levels have different effects in animals with different individual-typological characteristics. © 2014 Springer Science+Business Media.

引用

页码：672 / 680

页数：8

共 23 条

[1]

Zaichenko M.I., Merzhanova G.Kh., Studies of the occurrence of impulsivity in rats in a situation of choosing food reinforcements of different value, Zh. Vyssh. Nerv. Deyat., 60, 1, pp. 56-64, (2010)

[2]

Zaichenko M.I., Merzhanova G.Kh., Effects of blockade of dopamine D1/D2 receptors on behavior in rats differing in terms of the level of impulsivity and self-control, Zh. Vyssh. Nerv. Deyat., 61, 5, pp. 1-10, (2011)

[3]

Ivlieva N.Yu., Involvement of the mesocorticolimbic dopaminergic system in adaptive behavior, Zh. Vyssh. Nerv. Deyat., 60, 2, pp. 489-494, (2010)

[4]

Kuleshova E.P., Merzhanova G.Kh., Grigor'Yan G.A., Effects of blockade of dopaminergic D1/D2 receptors on behavioral strategy in cats in conditions of choosing reinforcements of different value, Zh. Vyssh. Nerv. Deyat., 56, 5, pp. 641-652, (2006)

[5]

Maiorov V.I., Frolov A.G., Effects of systemic administration of selective antagonists of D 1 and D2/3 receptors on food-related and defensive (escape reactions) paw placing conditioned reflexes in cats, Zh. Vyssh. Nerv. Deyat., 54, 4, pp. 489-494, (2004)

[6]

Sarkisova K.Yu., Kulikov M.A., Midzyanovskaya I.S., Folomkina A.A., The dopamine-dependent nature of depression-like behavior in Wag/Rij rats with genetic absence epilepsy, Zh. Vyssh. Nerv. Deyat., 57, 1, pp. 91-102, (2007)

[7]

Shapovalova K.B., Kamkina Yu. V., Comparison of the effects of systemic (intramuscular) and intrastriate administration of a selective D1 dopamine receptor blocker on motor behavior and postural rearrangement in dogs, Zh. Vyssh. Nerv. Deyat., 58, 5, pp. 584-595, (2008)

[8]

Beninger R.J., Miler R., Dopamine D1-like receptors and reward-related incentive learning, Neurosci. Biobehav. Res., 22, 2, pp. 335-345, (1998)

[9]

Berridge K.C., The debate over dopamine's role in reward: The case for incentive salience, Psychopharmacology (Berlin), 191, 3, pp. 391-431, (2007)

[10]

Cardinal R.N., Daw N., Robbins T.W., Everitt B.J., Local analysis of behaviour in the adjusting-delay task for assessing choice of delayed reinforcement, Neural Netw., 15, 4-6, pp. 617-634, (2002)

← 1 2 3 →