Lack of evidence for association between endothelial nitric oxide synthase gene polymorphism (glu298asp) with Behçet’s disease in the Turkish population

被引：0
作者：
Nurten Kara
Nilgun Senturk
Sezgin Ozgur Gunes
Hasan Bagci
Serbulent Yigit
Ahmet Yasar Turanli
机构：
[1] Ondokuz Mayis University,Department of Medical Biology and Genetics, Faculty of Medicine
[2] Ondokuz Mayis University,Department of Dermatology, Faculty of Medicine
来源：
Archives of Dermatological Research | 2006年 / 297卷
关键词：
Behçet’s disease; Nitric oxide synthase; gene polymorphism;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Endothelial nitric oxide synthase (eNOS) could be a candidate gene for Behçet’s disease (BD). This study investigated the relationship of the eNOS Glu298→Asp polymorphism with the presence and severity of BD in the Turkish population. Ninety-two patients with BD and 100 controls were studied. Analyses of Glu298Asp polymorphism in exon 7 of the eNOS gene were made by the polymerase chain reaction (PCR)-restriction fragment length polymorphism technique. The frequencies of the eNOS genotypes were similar for BD patients (GG:GT:TT=58.7%:38%:3.3%) and controls (59.2%:33.7%:7.1 %), P=0.335. No evidence of difference was found in the frequency of the T allele between BD patients (22.3%) and controls (24%), [OR=0.91, 95% CI (0.55–1.50), P=0.690]. Glu298→Asp polymorphism of the eNOS gene does not appear to be associated with the presence of BD in the Turkish population.
引用
收藏
页码：468 / 471
页数：3
相关论文
共 130 条
[1]  
Arayssi T(2004)New insights into the pathogenesis and therapy of Behçet’s disease Curr Opin Pharmacol 4 183-188
[2]  
Hamdan A(2003)Endothelial nitric oxide synthase gene polymorphisms and risk of coronary artery disease Clin Chem 49 1-5
[3]  
Colombo MG(2001)Relationship between the G894T polymorphism (Glu298 Asp Variant) in endothelial nitric oxide synthase and nitric oxide-mediated endothelial function in human atherosclerosis Am J Med Genet 100 130-137
[4]  
Paradossi U(1996)Impaired haemostatic kinetics and endothelial function in Behcet’s disease J Intern Med 240 181-187
[5]  
Andreassi MG(1998)Endothelial nitric oxide synthase gene polymorphism and acute myocardial infarction Hypertension 32 521-526
[6]  
Botto N(1999)A common variant of the endothelial nitric oxide synthase (Glu Circulation 100 1515-1520
[7]  
Manfreidi S(1990)→Asp) is a major risk factor for coronary artery disease in UK Lancet 335 1078-1080
[8]  
Masetti S(2005)Criteria for diagnosis of Behcet’s disease Rheumatology 44 614-617
[9]  
Biagini A(2005)Polymorphisms in the endothelial nitric oxide synthase gene are associated with Behçet’s disease Arthritis Rheum 52 1836-1842
[10]  
Clerico A(2003)Whole-genome screening for susceptibility genes in multicase families with Behçet’s disease Ann Rheum Dis 62 1083-1087
12345678910