Multimodal microtubule binding by the Ndc80 kinetochore complex

被引：0
作者：
Gregory M Alushin
Vivek Musinipally
Daniel Matson
John Tooley
P Todd Stukenberg
Eva Nogales
机构：
[1] Biophysics Graduate Group,Department of Molecular and Cell Biology
[2] University of California Berkeley,Department of Biochemistry and Molecular Genetics
[3] University of California Berkeley,Life Sciences Division
[4] University of Virginia School of Medicine,Department of Molecular and Cell Biology
[5] Lawrence Berkeley National Laboratory,undefined
[6] Howard Hughes Medical Institute,undefined
[7] University of California Berkeley,undefined
来源：
Nature Structural & Molecular Biology | 2012年 / 19卷
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学科分类号：
摘要：
Microtubules bind to the kinetochore at the Ndc80 complex, and this interaction is regulated by phosphorylation events at the N-terminal tail of Ndc80, mediated by the Aurora B kinase. The distinct functions of Ndc80 N-terminal tail are now dissected, revealing a region that binds tubulin and another that contacts the globular head of Ndc80. Both contacts are disrupted by phosphorylation, and the results lead to a mechanistic model for how phosphorylation of Ndc80 controls its interactions with microtubules.
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页码：1161 / 1167
页数：6
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