Multimodal microtubule binding by the Ndc80 kinetochore complex

被引：0

作者：

Gregory M Alushin

Vivek Musinipally

Daniel Matson

John Tooley

P Todd Stukenberg

Eva Nogales

机构：

[1] Biophysics Graduate Group,Department of Molecular and Cell Biology

[2] University of California Berkeley,Department of Biochemistry and Molecular Genetics

[3] University of California Berkeley,Life Sciences Division

[4] University of Virginia School of Medicine,Department of Molecular and Cell Biology

[5] Lawrence Berkeley National Laboratory,undefined

[6] Howard Hughes Medical Institute,undefined

[7] University of California Berkeley,undefined

来源：

Nature Structural & Molecular Biology | 2012年 / 19卷

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摘要：

Microtubules bind to the kinetochore at the Ndc80 complex, and this interaction is regulated by phosphorylation events at the N-terminal tail of Ndc80, mediated by the Aurora B kinase. The distinct functions of Ndc80 N-terminal tail are now dissected, revealing a region that binds tubulin and another that contacts the globular head of Ndc80. Both contacts are disrupted by phosphorylation, and the results lead to a mechanistic model for how phosphorylation of Ndc80 controls its interactions with microtubules.

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页码：1161 / 1167

页数：6

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