The BAH domain of ORC1 links H4K20me2 to DNA replication licensing and Meier–Gorlin syndrome

被引：0
|
作者：
Alex J. Kuo
Jikui Song
Peggie Cheung
Satoko Ishibe-Murakami
Sayumi Yamazoe
James K. Chen
Dinshaw J. Patel
Or Gozani
机构：
[1] Stanford University,Department of Biology
[2] Structural Biology Program,Department of Chemical and Systems Biology
[3] Memorial Sloan-Kettering Cancer Center,undefined
[4] Stanford School of Medicine,undefined
[5] Present address: Department of Biochemistry,undefined
[6] University of California,undefined
[7] Riverside,undefined
[8] California 92521,undefined
[9] USA.,undefined
来源：
Nature | 2012年 / 484卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The ORC1 BAH domain is shown to be a module that recognizes a histone modification associated with replication origins, providing insight into the aetiology of Meier–Gorlin syndrome.
引用
收藏
页码：115 / 119
页数：4
相关论文
共 45 条
  • [41] The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1 through Direct H4K20me Binding and H2AK15 Acetylation
    Jacquet, Karine
    Fradet-Turcotte, Amelie
    Avvakumov, Nikita
    Lambert, Jean-Philippe
    Roques, Celine
    Pandita, Raj K.
    Paquet, Eric
    Herst, Pauline
    Gingras, Anne-Claude
    Pandita, Tej K.
    Legube, Gaelle
    Doyon, Yannick
    Durocher, Daniel
    Cote, Jacques
    MOLECULAR CELL, 2016, 62 (03) : 409 - 421
  • [42] YTHDC1 is a therapeutic target for B-cell acute lymphoblastic leukemia by attenuating DNA damage response through the KMT2C-H3K4me1/me3 epigenetic axis
    Li, Xinxin
    Zheng, Minhua
    Ma, Shoubao
    Nie, Fengze
    Yin, Zhiqiang
    Liang, Yanan
    Yan, Xianchun
    Wen, Weihong
    Yu, Jianhua
    Liang, Yingmin
    Huang, Siyong
    Han, Hua
    LEUKEMIA, 2025, 39 (02) : 308 - 322
  • [43] Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair
    Botuyan, Maria Victoria
    Lee, Joseph
    Ward, Irene M.
    Kim, Ja-Eun
    Thompson, James R.
    Chen, Junjie
    Mer, Georges
    CELL, 2006, 127 (07) : 1361 - 1373
  • [44] Genistein-induced Anticancer Effects on Acute Leukemia Cells Involve the Regulation of Wnt Signaling Pathway Through H4K20me1 Rather Than DNA Demethylation (vol 41, pg 869, 2021)
    Zhou, Hua-rong
    Shen, Jian-zhen
    Fu, Hai-ying
    Zhang, Feng
    CURRENT MEDICAL SCIENCE, 2021, 41 (06) : 1257 - 1257
  • [45] LOW-TEMPERATURE NEUTRON-DIFFRACTION STUDIES OF C-H-METAL INTERACTIONS IN 2 TANTALUM-NEOPENTYLIDENE COMPLEXES - [TA(CHCME3)(PME3)CL3]2 [T=110K] AND THE 1ST ALKYLIDENE-OLEFIN COMPLEX, "TA(N5-C5ME5)(CHCME3)(N2-C2H4)(PME3) [T=20K]
    SCHULTZ, AJ
    BROWN, RK
    WILLIAMS, JM
    SCHROCK, RR
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1981, 103 (01) : 169 - 176
12345