The BAH domain of ORC1 links H4K20me2 to DNA replication licensing and Meier–Gorlin syndrome

被引:0
|
作者
Alex J. Kuo
Jikui Song
Peggie Cheung
Satoko Ishibe-Murakami
Sayumi Yamazoe
James K. Chen
Dinshaw J. Patel
Or Gozani
机构
[1] Stanford University,Department of Biology
[2] Structural Biology Program,Department of Chemical and Systems Biology
[3] Memorial Sloan-Kettering Cancer Center,undefined
[4] Stanford School of Medicine,undefined
[5] Present address: Department of Biochemistry,undefined
[6] University of California,undefined
[7] Riverside,undefined
[8] California 92521,undefined
[9] USA.,undefined
来源
Nature | 2012年 / 484卷
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摘要
The ORC1 BAH domain is shown to be a module that recognizes a histone modification associated with replication origins, providing insight into the aetiology of Meier–Gorlin syndrome.
引用
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页码:115 / 119
页数:4
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