Evaluation of the therapeutic potential of cerebrolysin and/or lithium in the male Wistar rat model of Parkinson’s disease induced by reserpine

被引：0
作者：
Engy K. Tharwat
Ahmed O. Abdelaty
Alaa I. Abdelrahman
Hebatallah Elsaeed
Ayatallah Elgohary
Amena S. El-Feky
Yasmina M. Ebrahim
Alaa Sakraan
Hossam A. Ismail
Yasser A. Khadrawy
Heba S. Aboul Ezz
Neveen A. Noor
Heba M. Fahmy
Haitham S. Mohammed
Faten F. Mohammed
Nasr M. Radwan
Nawal A. Ahmed
机构：
[1] Cairo University,Biotechnology Department, Faculty of Science
[2] Cairo University,Zoology Department, Faculty of Science
[3] Cairo University,Faculty of Medicine
[4] Badr University in Cairo,School of Biotechnology
[5] Cairo University,Department of Pharmacology and Toxicology, Faculty of Pharmacy
[6] Tanta University,Biophysics Department, Faculty of Science
[7] National Research Center,Medical Physiology Department, Medical Division
[8] Cairo University,Biophysics Department, Faculty of Science
[9] Cairo University,Faculty of Veterinary Medicine
[10] Cairo University,Department of Zoology, Faculty of Science
来源：
Metabolic Brain Disease | 2023年 / 38卷
关键词：
Parkinson’s disease; Cerebrolysin; Lithium; Monoamines; Oxidative stress; Inflammation;
D O I：
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中图分类号：
学科分类号：
摘要：
Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease worldwide and represents a challenge for clinicians. The present study aims to investigate the effects of cerebrolysin and/or lithium on the behavioral, neurochemical and histopathological alterations induced by reserpine as a model of PD. The rats were divided into control and reserpine-induced PD model groups. The model animals were further divided into four subgroups: rat PD model, rat PD model treated with cerebrolysin, rat PD model treated with lithium and rat PD model treated with a combination of cerebrolysin and lithium. Treatment with cerebrolysin and/or lithium ameliorated most of the alterations in oxidative stress parameters, acetylcholinesterase and monoamines in the striatum and midbrain of reserpine-induced PD model. It also ameliorated the changes in nuclear factor-kappa and improved the histopathological picture induced by reserpine. It could be suggested that cerebrolysin and/or lithium showed promising therapeutic potential against the variations induced in the reserpine model of PD. However, the ameliorating effects of lithium on the neurochemical, histopathological and behavioral alterations induced by reserpine were more prominent than those of cerebrolysin alone or combined with lithium. It can be concluded that the antioxidant and anti-inflammatory effects of both drugs played a significant role in their therapeutic potency.
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页码：1513 / 1529
页数：16
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共 371 条
  • [1] Abdel-Salam O(2013)Cerebrolysin attenuates cerebral and hepatic injury due to lipopolysaccharide in rats Drug Discoveries Therapeut 7 261-271
  • [2] Alzoubi KH(2018)Prevention of memory impairment induced by post-traumatic stress disorder by cerebrolysin Psychiat Res 270 430-437
  • [3] Al-Ibbini AM(2011)Treatment of depressive symptoms in Parkinson’s disease Eur J Neurol 18 11-15
  • [4] Nuseir KQ(1995)Dopamine neurotoxicity: inhibition of mitochondrial respiration J Neurochem 64 718-723
  • [5] Barone P(2007)Alpha-lipoic acid differently affects the reserpine-induced oxidative stress in the striatum and prefrontal cortex of rat brain Neuroscience 146 1758-1771
  • [6] Ben-Shachar D(2007)Identification and characterization of two nuclear factor-kappab sites in the regulatory region of the dopamine D2 receptor Endocrinology 148 2563-2570
  • [7] Zuk R(2019)Effects of lithium on inflammatory and neurotrophic factors after an immune challenge in a lisdexamfetamine animal model of mania Braz J Psychiat 41 419-427
  • [8] Glinka Y(2016)Chronic lithium treatment rectifies maladaptive dopamine release in the nucleus accumbens J Neurochem 139 576-585
  • [9] Bilska A(2018)Lithium improves dopamine neurotransmission and increases dopaminergic protein abundance in the striatum after traumatic brain injury J Neurotrauma 35 2827-2836
  • [10] Dubiel M(2008)Altered vesicular dopamine storage in Parkinson’s disease: a premature demise Trends Neurosci 31 303-308
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