Everolimus-induced epithelial to mesenchymal transition in immortalized human renal proximal tubular epithelial cells: key role of heparanase

被引:0
作者
Valentina Masola
Gianluigi Zaza
Simona Granata
Giovanni Gambaro
Maurizio Onisto
Antonio Lupo
机构
[1] University-Hospital of Verona,Renal Unit, Department of Medicine
[2] Columbus-Gemelli University Hospital,Division of Nephrology and Dialysis
[3] Renal Program,Department of Biomedical Sciences
[4] Catholic University,undefined
[5] University of Padova,undefined
来源
Journal of Translational Medicine | / 11卷
关键词
Epithelial-mesenchymal transition; Everolimus; Heparanase; mTOR; Tubular cells;
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[1]  
Geissler EK(2008)mTOR, cancer, and transplantation Am J Transplant 8 2212-2218
[2]  
Schlitt HJ(2007)Proliferation signal inhibitors in transplantation: questions at the cutting edge of everolimus therapy Transplant Proc 39 2937-2950
[3]  
Thomas G(1998)Rapamune (RAPA, rapamycin, sirolimus): mechanism of action immunnuosuppressive effect results from blockade of signal transduction and inhibition of cell cycle progression Clin Biochem 31 335-340
[4]  
Chapman JR(2005)Sirolimus for Kaposi’s sarcoma in renal-transplant recipients N Engl J Med 352 1317-1323
[5]  
Valantine H(2009)The VEGF pathway and the AKT/mTOR/p70S6K1 signalling pathway in human epithelial ovarian cancer Br J Cancer 100 971-978
[6]  
Albanell J(2010)Targeting mTOR pathway: a new concept in cancer therapy Indian J Med Paediatr Oncol 31 132-136
[7]  
Arns WA(2011)Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy J Clin Invest 121 1231-1241
[8]  
Campistol JM(2012)Treatment of advanced pancreatic neuroendocrine tumors: potential role of everolimus Onco Targets Ther 5 217-224
[9]  
Eisen H(2003)Tuberous sclerosis: from tubers to mTOR Ann Hum Genet 67 87-96
[10]  
Frigerio M(2006)Everolimus in clinical practice–renal transplantation Nephrol Dial Transplant 21 iii18-iii23